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- Active_zone abstract "The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make contact through structures called synapses allowing them to communicate with each other. As shown in the diagram on the right, a synapse consists of the presynaptic bouton of one neuron which stores vesicles containing neurotransmitter (uppermost in the picture) and a second, postsynaptic neuron which bears receptors for the neurotransmitter (at the bottom). When an action potential reaches the presynaptic bouton, the contents of the vesicles are released into the synaptic cleft and the released neurotransmitter travels across the cleft to the postsynaptic neuron (the lower structure in the picture) and activates the receptors on the postsynaptic membrane.The active zone is the region in the presynaptic bouton that mediates neurotransmitter release and is composed of the presynaptic membrane and a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ is seen under the electron microscope to be a dark (electron dense) area close to the membrane. Proteins within the CAZ tether synaptic vesicles to the presynaptic membrane and mediate synaptic vesicle fusion, thereby allowing neurotransmitter to be released reliably and rapidly when an action potential arrives.".
- Active_zone thumbnail Neuron_synapse.png?width=300.
- Active_zone wikiPageID "31153340".
- Active_zone wikiPageRevisionID "601285674".
- Active_zone caption "A diagram of a typical central nervous system synapse. The proteins of the active zone are represented as dark brown pyramids on the upper neuron terminal".
- Active_zone hasPhotoCollection Active_zone.
- Active_zone latin "zona activa".
- Active_zone name "Active zone".
- Active_zone subject Category:Cell_signaling.
- Active_zone subject Category:Cellular_neuroscience.
- Active_zone subject Category:Molecular_neuroscience.
- Active_zone subject Category:Neurobiology.
- Active_zone subject Category:Neurophysiology.
- Active_zone subject Category:Signal_transduction.
- Active_zone type Abstraction100002137.
- Active_zone type Anatomy106057539.
- Active_zone type Biology106037666.
- Active_zone type Cognition100023271.
- Active_zone type Content105809192.
- Active_zone type Discipline105996646.
- Active_zone type KnowledgeDomain105999266.
- Active_zone type LifeScience106037298.
- Active_zone type Morphology106078327.
- Active_zone type NaturalScience106000400.
- Active_zone type PsychologicalFeature100023100.
- Active_zone type Science105999797.
- Active_zone type AnatomicalStructure.
- Active_zone type BiologicalObject.
- Active_zone comment "The active zone or synaptic active zone is a term first used by Couteaux and Pecot-Dechavassinein in 1970 to define the site of neurotransmitter release. Two neurons make contact through structures called synapses allowing them to communicate with each other.".
- Active_zone label "Active zone".
- Active_zone sameAs m.0gh8x76.
- Active_zone sameAs Q4677599.
- Active_zone sameAs Q4677599.
- Active_zone sameAs Active_zone.
- Active_zone wasDerivedFrom Active_zone?oldid=601285674.
- Active_zone depiction Neuron_synapse.png.
- Active_zone isPrimaryTopicOf Active_zone.
- Active_zone name "Active zone".
