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- Alanine_racemase abstract "In enzymology, an alanine racemase (EC 5.1.1.1) is an enzyme that catalyzes the chemical reactionL-alanine D-alanineHence, this enzyme has one substrate, L-alanine, and one product, D-alanine.This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is alanine racemase. This enzyme is also called L-alanine racemase. This enzyme participates in alanine and aspartate metabolism and D-alanine metabolism. It employs one cofactor, pyridoxal phosphate. At least two compounds, 3-Fluoro-D-alanine and D-Cycloserine are known to inhibit this enzyme.The D-alanine produced by alanine racemase is used for peptidoglycan biosynthesis. Peptidoglycan is found in the cell walls of all bacteria, including many which are harmful to humans. The enzyme is absent in eukaryotes but found everywhere in prokaryotes, making alanine racemase a great target for antimicrobial drug development .Bacteria can have one (alr gene) or two alanine racemase genes. Bacterial species with two genes for alanine racemase have one that is continually expressed and one that is inducible, which makes it difficult to target both genes for drug studies. However, knockout studies have shown that without the alr gene being expressed, the bacteria would need an external source of D-alanine in order to survive. Therefore, the alr gene is a feasible target for antimicrobial drugs .".
- Alanine_racemase ecNumber "5.1.1.1".
- Alanine_racemase thumbnail PDB_1rcq_EBI.jpg?width=300.
- Alanine_racemase wikiPageID "14212744".
- Alanine_racemase wikiPageRevisionID "606794163".
- Alanine_racemase caption "The 1.45Å a crystal structure of alanine racemase from Pseudomonas aeruginosa, PDB 1rcq".
- Alanine_racemase caption "the 1.45Å a crystal structure of alanine racemase from a pathogenic bacterium, pseudomonas aeruginosa, contains both internal and external aldimine forms".
- Alanine_racemase casNumber "9024".
- Alanine_racemase ecNumber "5.1".
- Alanine_racemase goCode "8784".
- Alanine_racemase hasPhotoCollection Alanine_racemase.
- Alanine_racemase interpro "IPR001608".
- Alanine_racemase interpro "IPR011079".
- Alanine_racemase iubmbEcNumber "5".
- Alanine_racemase name "Ala_racemase_C".
- Alanine_racemase name "Ala_racemase_N".
- Alanine_racemase name "alanine racemase".
- Alanine_racemase pfam "PF00842".
- Alanine_racemase pfam "PF01168".
- Alanine_racemase pfamClan "CL0036".
- Alanine_racemase prosite "PDOC00332".
- Alanine_racemase scop "1".
- Alanine_racemase symbol "Ala_racemase_C".
- Alanine_racemase symbol "Ala_racemase_N".
- Alanine_racemase subject Category:EC_5.1.1.
- Alanine_racemase subject Category:Enzymes_of_known_structure.
- Alanine_racemase subject Category:Pyridoxal_phosphate_enzymes.
- Alanine_racemase type Abstraction100002137.
- Alanine_racemase type Activator114723079.
- Alanine_racemase type Catalyst114723628.
- Alanine_racemase type Chemical114806838.
- Alanine_racemase type Compound114818238.
- Alanine_racemase type Enzyme114732946.
- Alanine_racemase type EnzymesOfKnownStructure.
- Alanine_racemase type Macromolecule114944888.
- Alanine_racemase type Material114580897.
- Alanine_racemase type Matter100020827.
- Alanine_racemase type Molecule114682133.
- Alanine_racemase type OrganicCompound114727670.
- Alanine_racemase type Part113809207.
- Alanine_racemase type PhysicalEntity100001930.
- Alanine_racemase type Protein114728724.
- Alanine_racemase type PyridoxalPhosphateEnzymes.
- Alanine_racemase type Relation100031921.
- Alanine_racemase type Substance100019613.
- Alanine_racemase type Thing100002452.
- Alanine_racemase type Unit109465459.
- Alanine_racemase type Biomolecule.
- Alanine_racemase type Enzyme.
- Alanine_racemase type BiologicalObject.
- Alanine_racemase comment "In enzymology, an alanine racemase (EC 5.1.1.1) is an enzyme that catalyzes the chemical reactionL-alanine D-alanineHence, this enzyme has one substrate, L-alanine, and one product, D-alanine.This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is alanine racemase. This enzyme is also called L-alanine racemase.".
- Alanine_racemase label "Alanine racemase".
- Alanine_racemase label "アラニンラセマーゼ".
- Alanine_racemase sameAs アラニンラセマーゼ.
- Alanine_racemase sameAs m.03cx_3b.
- Alanine_racemase sameAs Q4708245.
- Alanine_racemase sameAs Q4708245.
- Alanine_racemase sameAs 2453.
- Alanine_racemase sameAs 894.
- Alanine_racemase sameAs Alanine_racemase.
- Alanine_racemase wasDerivedFrom Alanine_racemase?oldid=606794163.
- Alanine_racemase depiction PDB_1rcq_EBI.jpg.
- Alanine_racemase isPrimaryTopicOf Alanine_racemase.
- Alanine_racemase name "alanine racemase".