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- Alpha-2-Macroglobulin abstract "alpha-2-Macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.Alpha-2-Macroglobulin is the largest major nonimmunoglobulin protein in plasma. The alpha-2-macroglobulin molecule is synthesized mainly in liver, but also locally by macrophages, fibroblasts, and adrenocortical cells.Alpha 2 macroglobulin acts as an antiprotease and is able to inactivate an enormous variety of proteinases. It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It functions as an inhibitor of coagulation by inhibiting thrombin. Alpha-2-macroglobulin may act as a carrier protein because it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β.No specific deficiency with associated disease has been recognized, and no disease state is attributed to low concentrations of alpha-2-macroglobulin.The concentration of alpha-2-macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are lost in the urine. The loss of alpha-2-macroglobulin into urine is prevented by its large size. The net result is that alpha-2-macroglobulin reaches serum levels equal to or greater than those of albumin in the nephrotic syndrome, which has the effect of maintaining oncotic pressure.".
- Alpha-2-Macroglobulin arm "p".
- Alpha-2-Macroglobulin band "13".
- Alpha-2-Macroglobulin chromosome "12".
- Alpha-2-Macroglobulin entrezgene "2".
- Alpha-2-Macroglobulin hgncid "7".
- Alpha-2-Macroglobulin locusSupplementaryData ".31".
- Alpha-2-Macroglobulin omim "103950".
- Alpha-2-Macroglobulin refseq "NM_000014".
- Alpha-2-Macroglobulin symbol "A2M".
- Alpha-2-Macroglobulin symbol "A2M_N".
- Alpha-2-Macroglobulin symbol "A2M_N_2".
- Alpha-2-Macroglobulin symbol "A2M_comp".
- Alpha-2-Macroglobulin symbol "A2M_recep".
- Alpha-2-Macroglobulin thumbnail 2P9R.png?width=300.
- Alpha-2-Macroglobulin uniprot "P01023".
- Alpha-2-Macroglobulin wikiPageExternalLink merops.cgi?id=I39.001.
- Alpha-2-Macroglobulin wikiPageExternalLink explore.do?pdbId=2P9R.
- Alpha-2-Macroglobulin wikiPageID "555663".
- Alpha-2-Macroglobulin wikiPageRevisionID "606056370".
- Alpha-2-Macroglobulin arm "p".
- Alpha-2-Macroglobulin band "13".
- Alpha-2-Macroglobulin caption "Crystal structure of alpha-2-macroglobulin. Rendered from PDB 2P9R.".
- Alpha-2-Macroglobulin caption "crystal structure of tep1r".
- Alpha-2-Macroglobulin caption "human complement component 5".
- Alpha-2-Macroglobulin caption "n-terminally truncated c3dg fragment".
- Alpha-2-Macroglobulin caption "receptor domain from alpha-2-macroglobulin".
- Alpha-2-Macroglobulin caption "structure of mammalian c3 with an intact thioester at 3a resolution".
- Alpha-2-Macroglobulin chromosome "12".
- Alpha-2-Macroglobulin entrezgene "2".
- Alpha-2-Macroglobulin hasPhotoCollection Alpha-2-Macroglobulin.
- Alpha-2-Macroglobulin hgncid "7".
- Alpha-2-Macroglobulin interpro "IPR001599".
- Alpha-2-Macroglobulin interpro "IPR002890".
- Alpha-2-Macroglobulin interpro "IPR009048".
- Alpha-2-Macroglobulin interpro "IPR011625".
- Alpha-2-Macroglobulin interpro "IPR011626".
- Alpha-2-Macroglobulin locussupplementarydata "0.31".
- Alpha-2-Macroglobulin name "A-macroglobulin complement component".
- Alpha-2-Macroglobulin name "A2M receptor domain region".
- Alpha-2-Macroglobulin name "Alpha-2-macroglobulin family N-terminal region".
- Alpha-2-Macroglobulin name "Alpha-2-macroglobulin family".
- Alpha-2-Macroglobulin name "MG2 domain".
- Alpha-2-Macroglobulin name "alpha-2-macroglobulin".
- Alpha-2-Macroglobulin omim "103950".
- Alpha-2-Macroglobulin pfam "PF00207".
- Alpha-2-Macroglobulin pfam "PF01835".
- Alpha-2-Macroglobulin pfam "PF07677".
- Alpha-2-Macroglobulin pfam "PF07678".
- Alpha-2-Macroglobulin pfam "PF07703".
- Alpha-2-Macroglobulin pfamClan "CL0011".
- Alpha-2-Macroglobulin pfamClan "CL0059".
- Alpha-2-Macroglobulin pfamClan "CL0159".
- Alpha-2-Macroglobulin prosite "PDOC00440".
- Alpha-2-Macroglobulin refseq "NM_000014".
- Alpha-2-Macroglobulin scop "1".
- Alpha-2-Macroglobulin scop "2".
- Alpha-2-Macroglobulin scop "259200.0".
- Alpha-2-Macroglobulin symbol "A2M".
- Alpha-2-Macroglobulin symbol "A2M_N".
- Alpha-2-Macroglobulin symbol "A2M_N_2".
- Alpha-2-Macroglobulin symbol "A2M_comp".
- Alpha-2-Macroglobulin symbol "A2M_recep".
- Alpha-2-Macroglobulin uniprot "P01023".
- Alpha-2-Macroglobulin subject Category:Acute_phase_proteins.
- Alpha-2-Macroglobulin type Biomolecule.
- Alpha-2-Macroglobulin type Protein.
- Alpha-2-Macroglobulin type ProteinMolecule.
- Alpha-2-Macroglobulin type BiologicalObject.
- Alpha-2-Macroglobulin comment "alpha-2-Macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.Alpha-2-Macroglobulin is the largest major nonimmunoglobulin protein in plasma.".
- Alpha-2-Macroglobulin label "Alfa-2 macroglobulina".
- Alpha-2-Macroglobulin label "Alfa2-macroglobulina".
- Alpha-2-Macroglobulin label "Alpha-2 macroglobuline".
- Alpha-2-Macroglobulin label "Alpha-2-Globulin".
- Alpha-2-Macroglobulin label "Alpha-2-Macroglobulin".
- Alpha-2-Macroglobulin sameAs Alpha-2-Globulin.
- Alpha-2-Macroglobulin sameAs Alfa-2_macroglobulina.
- Alpha-2-Macroglobulin sameAs Alpha-2_macroglobuline.
- Alpha-2-Macroglobulin sameAs Alfa2-macroglobulina.
- Alpha-2-Macroglobulin sameAs m.02kgmjl.
- Alpha-2-Macroglobulin sameAs Q289013.
- Alpha-2-Macroglobulin sameAs Q289013.
- Alpha-2-Macroglobulin wasDerivedFrom Alpha-2-Macroglobulin?oldid=606056370.
- Alpha-2-Macroglobulin depiction 2P9R.png.
- Alpha-2-Macroglobulin isPrimaryTopicOf Alpha-2-Macroglobulin.
- Alpha-2-Macroglobulin name "alpha-2-macroglobulin".