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- Alpha_defensin abstract "Alpha defensins are a family of mammalian defensin peptides.Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses, containing three pairs of intramolecular disulfide bonds. On the basis of their size and pattern of disulfide bonding, mammalian defensins are classified into alpha, beta and theta categories. Alpha-defensins, which have been identified in humans, monkeys and several rodent species, are particularly abundant in neutrophils, certain macrophage populations and Paneth cells of the small intestine.Defensins are produced constitutively and/or in response to microbial products or proinflammatory cytokines. Some defensins are also called corticostatins (CS) because they inhibit corticotropin-stimulated corticosteroid production. The mechanism(s) by which microorganisms are killed and/or inactivated by defensins is not understood completely. However, it is generally believed that killing is a consequence of disruption of the microbial membrane. The polar topology of defensins, with spatially separated charged and hydrophobic regions, allows them to insert themselves into the phospholipid membranes so that their hydrophobic regions are buried within the lipid membrane interior and their charged (mostly cationic) regions interact with anionic phospholipid head groups and water. Subsequently, some defensins can aggregate to form 'channel-like' pores; others might bind to and cover the microbial membrane in a 'carpet-like' manner. The net outcome is the disruption of membrane integrity and function, which ultimately leads to the lysis of microorganisms. Some defensins are synthesized as propeptides which may be relevant to this process.".
- Alpha_defensin symbol "Defensin_1".
- Alpha_defensin thumbnail PDB_1dfn_EBI.jpg?width=300.
- Alpha_defensin wikiPageID "14667909".
- Alpha_defensin wikiPageRevisionID "597649847".
- Alpha_defensin caption "Structure of defensin HNP-3.".
- Alpha_defensin hasPhotoCollection Alpha_defensin.
- Alpha_defensin interpro "IPR006081".
- Alpha_defensin name "Mammalian defensin".
- Alpha_defensin opmFamily "56".
- Alpha_defensin opmProtein "1".
- Alpha_defensin pdb "A:64-89 A:66-94 B:66-94 A:66-94 B:66-94".
- Alpha_defensin pfam "PF00323".
- Alpha_defensin prosite "PDOC00242".
- Alpha_defensin scop "1".
- Alpha_defensin symbol "Defensin_1".
- Alpha_defensin tcdb "1".
- Alpha_defensin subject Category:Peripheral_membrane_proteins.
- Alpha_defensin subject Category:Protein_domains.
- Alpha_defensin type Abstraction100002137.
- Alpha_defensin type Attribute100024264.
- Alpha_defensin type Chemical114806838.
- Alpha_defensin type Compound114818238.
- Alpha_defensin type Environment113934596.
- Alpha_defensin type Macromolecule114944888.
- Alpha_defensin type Material114580897.
- Alpha_defensin type Matter100020827.
- Alpha_defensin type Molecule114682133.
- Alpha_defensin type OrganicCompound114727670.
- Alpha_defensin type Part113809207.
- Alpha_defensin type PeripheralMembraneProteins.
- Alpha_defensin type PhysicalEntity100001930.
- Alpha_defensin type Protein114728724.
- Alpha_defensin type ProteinDomains.
- Alpha_defensin type Relation100031921.
- Alpha_defensin type Situation113927383.
- Alpha_defensin type Sphere114514039.
- Alpha_defensin type State100024720.
- Alpha_defensin type Substance100019613.
- Alpha_defensin type Thing100002452.
- Alpha_defensin type Unit109465459.
- Alpha_defensin type Biomolecule.
- Alpha_defensin type Protein.
- Alpha_defensin type BiologicalObject.
- Alpha_defensin comment "Alpha defensins are a family of mammalian defensin peptides.Defensins are 2-6 kDa, cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses, containing three pairs of intramolecular disulfide bonds. On the basis of their size and pattern of disulfide bonding, mammalian defensins are classified into alpha, beta and theta categories.".
- Alpha_defensin label "Alpha defensin".
- Alpha_defensin label "Α-defensyny".
- Alpha_defensin label "Альфа-дефензин".
- Alpha_defensin sameAs Α-defensyny.
- Alpha_defensin sameAs m.03gsfs0.
- Alpha_defensin sameAs Q4063641.
- Alpha_defensin sameAs Q4063641.
- Alpha_defensin sameAs Alpha_defensin.
- Alpha_defensin wasDerivedFrom Alpha_defensin?oldid=597649847.
- Alpha_defensin depiction PDB_1dfn_EBI.jpg.
- Alpha_defensin isPrimaryTopicOf Alpha_defensin.