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- Alpha_sheet abstract "Alpha sheet (also known as alpha pleated sheet or polar pleated sheet) is an atypical secondary structure in proteins, first proposed by Linus Pauling and Robert Corey in 1951. The hydrogen bonding pattern in an alpha sheet is similar to that of a beta sheet, but the orientation of the carbonyl and amino groups in the peptide bond units is distinctive; in a single alpha strand, all of the carbonyl groups are oriented in the same direction on one side of the pleat, and all of the amino groups are oriented in the same direction on the opposite side of the sheet. Thus the alpha sheet accumulates an inherent separation of electrostatic charge, with one edge of the sheet exposing negatively charged carbonyl groups and the opposite edge exposing positively charged amino groups. Unlike the alpha helix and beta sheet, the alpha sheet configuration does not require all component amino acid residues to lie within a single region of dihedral angles; instead, the alpha sheet contains residues of alternating dihedrals in the traditional right-handed (αR) and left-handed (αL) helical regions of Ramachandran space. Although the alpha sheet is only rarely observed in natural protein structures, it has been speculated to play a role in amyloid disease and it was found to be a stable form for amyloidogenic proteins in one set of molecular dynamics simulations. Alpha sheets have also been observed in X-ray crystallography structures of designed peptides.".
- Alpha_sheet thumbnail Alpha_sheet_bonding_schematic-color.svg?width=300.
- Alpha_sheet wikiPageID "9015477".
- Alpha_sheet wikiPageRevisionID "602278324".
- Alpha_sheet hasPhotoCollection Alpha_sheet.
- Alpha_sheet subject Category:Protein_structural_motifs.
- Alpha_sheet type Artifact100021939.
- Alpha_sheet type Decoration103169390.
- Alpha_sheet type Design103178782.
- Alpha_sheet type Motif103789014.
- Alpha_sheet type Object100002684.
- Alpha_sheet type PhysicalEntity100001930.
- Alpha_sheet type ProteinStructuralMotifs.
- Alpha_sheet type Whole100003553.
- Alpha_sheet comment "Alpha sheet (also known as alpha pleated sheet or polar pleated sheet) is an atypical secondary structure in proteins, first proposed by Linus Pauling and Robert Corey in 1951.".
- Alpha_sheet label "Alpha sheet".
- Alpha_sheet label "Lámina alfa".
- Alpha_sheet label "Αシート".
- Alpha_sheet sameAs Lámina_alfa.
- Alpha_sheet sameAs Αシート.
- Alpha_sheet sameAs m.027th6b.
- Alpha_sheet sameAs Q3266384.
- Alpha_sheet sameAs Q3266384.
- Alpha_sheet sameAs Alpha_sheet.
- Alpha_sheet wasDerivedFrom Alpha_sheet?oldid=602278324.
- Alpha_sheet depiction Alpha_sheet_bonding_schematic-color.svg.
- Alpha_sheet isPrimaryTopicOf Alpha_sheet.