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- Alstonine abstract "Alstonine is an indole alkaloid and putative antipsychotic constituent of various plant species including Alstonia boonei, Catharanthus roseus, Picralima nitida, Rauwolfia caffra and Rauwolfia vomitoria. In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working memory deficit and social withdrawal. It also possesses anxiolytic-like effects in preclinical studies. It also attenuates amfetamine-induced lethality and stereotypy as well as apomorphine-induced stereotypy. It also attenuates haloperidol-induced catalepsy. These effects appear to be mediated by stimulation of the 5-HT2C receptor. It also, similarly to clozapine, inhibits the reuptake of glutamate in hippocampal slices. Unlike clozapine, however, it lacks pro-convulsant activity in mice.".
- Alstonine atcPrefix "none".
- Alstonine iupacName "(19α,20α)-16-(Methoxycarbonyl)-19-methyl-3,4,5,6,16,17-hexadehydro-18-oxayohimban-4-ium".
- Alstonine pubchem "441979".
- Alstonine thumbnail Alstonine2DACS3.svg?width=300.
- Alstonine wikiPageID "41257608".
- Alstonine wikiPageRevisionID "587637477".
- Alstonine atcPrefix "none".
- Alstonine c "21".
- Alstonine chemspiderid "149308".
- Alstonine drugName "Alstonine".
- Alstonine h "21".
- Alstonine iupacName "-16".
- Alstonine molecularWeight "349.402496".
- Alstonine n "2".
- Alstonine o "3".
- Alstonine pubchem "441979".
- Alstonine smiles "O=C\C1=C\O[C@H]C".
- Alstonine stdinchi "InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-1822-20199-15172125-2/h3-8,11-12,15-16H,9-10H2,1-2H3/p+1/t12-,15-,16-/m0/s1".
- Alstonine stdinchikey "WYTGDNHDOZPMIW-RCBQFDQVSA-O".
- Alstonine width "200".
- Alstonine subject Category:Antipsychotics.
- Alstonine subject Category:Indole_alkaloids.
- Alstonine subject Category:Serotonin_receptor_agonists.
- Alstonine type Drug.
- Alstonine type FunctionalSubstance.
- Alstonine comment "Alstonine is an indole alkaloid and putative antipsychotic constituent of various plant species including Alstonia boonei, Catharanthus roseus, Picralima nitida, Rauwolfia caffra and Rauwolfia vomitoria. In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working memory deficit and social withdrawal. It also possesses anxiolytic-like effects in preclinical studies. It also attenuates amfetamine-induced lethality and stereotypy as well as apomorphine-induced stereotypy.".
- Alstonine label "Alstonine".
- Alstonine sameAs m.0zg7j9g.
- Alstonine sameAs Q15708035.
- Alstonine sameAs Q15708035.
- Alstonine wasDerivedFrom Alstonine?oldid=587637477.
- Alstonine depiction Alstonine2DACS3.svg.
- Alstonine isPrimaryTopicOf Alstonine.
- Alstonine name "Alstonine".