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- Amphotericin_B abstract "Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentous bacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's amphoteric properties. Two amphotericins, amphotericin A and amphotericin B are known, but only B is used clinically, because it is significantly more active in vivo. Amphotericin A is almost identical to amphotericin B (having a double C=C bond between the 27th and 28th carbons), but has little antifungal activity.[citation needed]Currently, the drug is available as plain amphotericin B, as a cholesteryl sulfate complex (ABCD), as a lipid complex (ABLC), and as a liposomal formulation (LAmB). The latter formulations have been developed to improve tolerability for the patient, but may show considerably different pharmacokinetic characteristics compared to plain amphotericin B.[citation needed]".
- Amphotericin_B atcPrefix "A01".
- Amphotericin_B atcSuffix "AB04".
- Amphotericin_B atcSupplemental ", ,".
- Amphotericin_B bioavailability "100.0".
- Amphotericin_B casNumber "1397-89-3".
- Amphotericin_B chEBI "2682".
- Amphotericin_B drugbank "DB00681".
- Amphotericin_B iupacName "(1R,3S,5R,6R,9R, 11R,15S,16R,17R,18S,19E,21E, 23E,25E,27E,29E,31E,33R,35S,36R,37S)- 33-[(3-amino- 3,6-dideoxy- β-(D)-mannopyranosyl)oxy]- 1,3,5,6,9,11,17,37-octahydroxy- 15,16,18-trimethyl- 13-oxo- 14,39-dioxabicyclo [33.3.1] nonatriaconta- 19,21,23,25,27,29,31-heptaene- 36-carboxylic acid".
- Amphotericin_B pubchem "14956".
- Amphotericin_B thumbnail Amphotericin_B_new.svg?width=300.
- Amphotericin_B wikiPageExternalLink www.ambisome.com.
- Amphotericin_B wikiPageExternalLink Ijpbst_2013_01_01.pdf.
- Amphotericin_B wikiPageExternalLink showBackIssue.asp?issn=0022-3859;year=2005;volume=51;issue=5;month=October–December.
- Amphotericin_B wikiPageID "732448".
- Amphotericin_B wikiPageRevisionID "605286184".
- Amphotericin_B atcPrefix "A01".
- Amphotericin_B atcSuffix "AB04".
- Amphotericin_B atcSupplemental ", ,".
- Amphotericin_B bioavailability "100.0".
- Amphotericin_B c "47".
- Amphotericin_B casNumber "1397".
- Amphotericin_B chebi "2682".
- Amphotericin_B chembl "267345".
- Amphotericin_B chemspiderid "10237579".
- Amphotericin_B drugbank "DB00681".
- Amphotericin_B eliminationHalfLife "1296000.0".
- Amphotericin_B eliminationHalfLife "86400.0".
- Amphotericin_B excretion "40".
- Amphotericin_B excretion "biliar excretion also important".
- Amphotericin_B h "73".
- Amphotericin_B hasPhotoCollection Amphotericin_B.
- Amphotericin_B image "Amphotericin b.gif".
- Amphotericin_B iupacName "-33".
- Amphotericin_B kegg "D00203".
- Amphotericin_B legalStatus "Rx-only, hospitalization recommended.".
- Amphotericin_B metabolism "renal".
- Amphotericin_B molecularWeight "923.49".
- Amphotericin_B n "1".
- Amphotericin_B niaidChemdb "96".
- Amphotericin_B o "17".
- Amphotericin_B pregnancyUs "B".
- Amphotericin_B pubchem "14956".
- Amphotericin_B routesOfAdministration "I.V. tropical".
- Amphotericin_B smiles "O=C[C@@H]3[C@@H]C[C@@]2C[C@@H]C[C@@H][C@H]CC[C@@H]C[C@@H]CCO[C@@H][C@H][C@H][C@@H]C=CC=CC=CC=CC=CC=CC=C[C@H]C[C@@H]3O2".
- Amphotericin_B stdinchi "1".
- Amphotericin_B stdinchikey "APKFDSVGJQXUKY-INPOYWNPSA-N".
- Amphotericin_B tradename "Fungizone".
- Amphotericin_B verifiedrevid "477002307".
- Amphotericin_B watchedfields "changed".
- Amphotericin_B subject Category:Antifungals.
- Amphotericin_B subject Category:Antifungals_for_dermatologic_use.
- Amphotericin_B subject Category:Gilead_Sciences.
- Amphotericin_B subject Category:Polyketide_antibiotics.
- Amphotericin_B subject Category:World_Health_Organization_essential_medicines.
- Amphotericin_B type Agent114778436.
- Amphotericin_B type Antibacterial102716205.
- Amphotericin_B type Antibiotic102716866.
- Amphotericin_B type Antifungal102720201.
- Amphotericin_B type Antifungals.
- Amphotericin_B type CausalAgent100007347.
- Amphotericin_B type Drug103247620.
- Amphotericin_B type Matter100020827.
- Amphotericin_B type Medicine103740161.
- Amphotericin_B type PhysicalEntity100001930.
- Amphotericin_B type PolyketideAntibiotics.
- Amphotericin_B type Substance100020090.
- Amphotericin_B type Drug.
- Amphotericin_B type DrugProduct.
- Amphotericin_B type FunctionalSubstance.
- Amphotericin_B comment "Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentous bacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's amphoteric properties.".
- Amphotericin_B label "Amfotericina B".
- Amphotericin_B label "Amfoterycyna B".
- Amphotericin_B label "Amphotericin B".
- Amphotericin_B label "Amphotericin B".
- Amphotericin_B label "Amphotéricine B".
- Amphotericin_B label "Anfotericina B".
- Amphotericin_B label "Anfotericina B".
- Amphotericin_B label "Амфотерицин B".
- Amphotericin_B label "أمفوتيريسين ب".
- Amphotericin_B label "アムホテリシンB".
- Amphotericin_B label "两性霉素B".
- Amphotericin_B sameAs Amphotericin_B.
- Amphotericin_B sameAs Anfotericina_B.
- Amphotericin_B sameAs B_anfoterizina.
- Amphotericin_B sameAs Amphotéricine_B.
- Amphotericin_B sameAs Amfotericina_B.
- Amphotericin_B sameAs アムホテリシンB.
- Amphotericin_B sameAs Amfoterycyna_B.
- Amphotericin_B sameAs Anfotericina_B.
- Amphotericin_B sameAs m.036l_4.
- Amphotericin_B sameAs Q412223.
- Amphotericin_B sameAs Q412223.
- Amphotericin_B sameAs amphotericin_B.
- Amphotericin_B sameAs DB00681.
- Amphotericin_B sameAs 1972.
- Amphotericin_B sameAs Amphotericin_B.
- Amphotericin_B wasDerivedFrom Amphotericin_B?oldid=605286184.
- Amphotericin_B depiction Amphotericin_B_new.svg.
- Amphotericin_B isPrimaryTopicOf Amphotericin_B.
