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- Anavex_Life_Sciences abstract "Anavex Life Sciences Corp. is a pharmaceutical company that develops drug candidates to treat serious and life-threatening medical conditions. The company's most advanced compound is ANAVEX 2-73, developed to treat Alzheimer’s disease through disease modification (i.e. could slow down, reverse or prevent Alzheimer’s disease).ANAVEX 2-73 demonstrated anti-amnesic and neuroprotective effects in pre-clinical studies conducted in France and other EU institutes. Based on these pre-clinical studies, the company sponsored a Phase 1 clinical trial on humans in 2011. The Phase 1 human trial was completed in Germany in collaboration with ABX-CRO Advanced Pharmaceutical Services (ABX-CRO). Results regarding the compound’s safety profile showed no evidence of any treatment-related adverse effects. In the Phase 1 trial, ANAVEX 2-73 was well tolerated by study subjects in doses up to 55 mg, with only mild adverse events in some volunteers. This dose is above the equivalent dose shown to have positive effects in mouse models of Alzheimer's disease. Observed adverse events at doses above the maximum tolerated single dose included headache and dizziness, which were moderate in severity and reversible. These side effects are often seen with drugs that target central nervous system conditions, including Alzheimer's disease.ANAVEX 2-73 has been shown to provide protection from oxidative stress, which damages and destroys neurons and is believed to be a primary cause of Alzheimer's disease. Research in recent years indicates that oxidative stress is a precursor to amyloid-beta plaques and tau (see also Neuro-Fibrillary Tangles), and could be a novel and appropriate therapeutic target.The company's proprietary SIGMACEPTOR™ Discovery Platform has generated small molecule drug candidates with unique modes of action, by making use of Anavex's understanding of sigma receptors. Sigma receptors represent potential targets for therapeutics to potentially combat many human diseases, including Alzheimer’s. When bound by the appropriate ligands, these receptors influence the functioning of multiple biochemical signals that are involved in the pathogenesis of disease.".
- Anavex_Life_Sciences industry Biopharmaceutical.
- Anavex_Life_Sciences locationCity New_York.
- Anavex_Life_Sciences locationCountry United_States.
- Anavex_Life_Sciences type Public_company.
- Anavex_Life_Sciences wikiPageExternalLink overview.asp.
- Anavex_Life_Sciences wikiPageExternalLink www.anavex.com.
- Anavex_Life_Sciences wikiPageExternalLink www.anavex.com.
- Anavex_Life_Sciences wikiPageExternalLink publications.html.
- Anavex_Life_Sciences wikiPageExternalLink 978-0-387-36512-1.
- Anavex_Life_Sciences wikiPageID "19234460".
- Anavex_Life_Sciences wikiPageRevisionID "589757799".
- Anavex_Life_Sciences advert "September 2008".
- Anavex_Life_Sciences hasPhotoCollection Anavex_Life_Sciences.
- Anavex_Life_Sciences homepage www.anavex.com.
- Anavex_Life_Sciences industry "Biopharmaceuticals".
- Anavex_Life_Sciences keyPeople "Christopher U. Missling, MS, PhD, MBA, President and CEO".
- Anavex_Life_Sciences keyPeople "Jeffrey Cummings, MD, Scientific Advisory Board – Clinical Expert".
- Anavex_Life_Sciences keyPeople "Michael Gold, MD, Scientific Advisory Board".
- Anavex_Life_Sciences keyPeople "Ottavio Arancio, MD, PhD, Scientific Advisory Board".
- Anavex_Life_Sciences keyPeople "Paul Aisen, MD, Scientific Advisory Board – Clinical Expert".
- Anavex_Life_Sciences keyPeople "Tangui Nicolas Maurice, Ph.D., Scientific Advisory Board".
- Anavex_Life_Sciences keyPeople "Tom Skarpelos, Director".
- Anavex_Life_Sciences locationCity New_York.
- Anavex_Life_Sciences locationCountry United_States.
- Anavex_Life_Sciences logo "200".
- Anavex_Life_Sciences name "Anavex Life Sciences Corp.".
- Anavex_Life_Sciences orphan "February 2009".
- Anavex_Life_Sciences primarysources "September 2008".
- Anavex_Life_Sciences type "Public".
- Anavex_Life_Sciences subject Category:Alzheimer's_disease_researchers.
- Anavex_Life_Sciences subject Category:Clinical_research.
- Anavex_Life_Sciences subject Category:Companies_of_Canada.
- Anavex_Life_Sciences subject Category:Drug_discovery.
- Anavex_Life_Sciences subject Category:Drug_discovery_companies.
- Anavex_Life_Sciences subject Category:Pharmaceutical_industry.
- Anavex_Life_Sciences subject Category:Pharmacology.
- Anavex_Life_Sciences type Abstraction100002137.
- Anavex_Life_Sciences type CompaniesBasedInGeneva.
- Anavex_Life_Sciences type Company108058098.
- Anavex_Life_Sciences type DrugCompany108002578.
- Anavex_Life_Sciences type Group100031264.
- Anavex_Life_Sciences type Institution108053576.
- Anavex_Life_Sciences type Organization108008335.
- Anavex_Life_Sciences type PharmaceuticalCompanies.
- Anavex_Life_Sciences type SocialGroup107950920.
- Anavex_Life_Sciences type YagoLegalActor.
- Anavex_Life_Sciences type YagoLegalActorGeo.
- Anavex_Life_Sciences type YagoPermanentlyLocatedEntity.
- Anavex_Life_Sciences type Agent.
- Anavex_Life_Sciences type Company.
- Anavex_Life_Sciences type Organisation.
- Anavex_Life_Sciences type Organization.
- Anavex_Life_Sciences type Agent.
- Anavex_Life_Sciences type SocialPerson.
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- Anavex_Life_Sciences comment "Anavex Life Sciences Corp. is a pharmaceutical company that develops drug candidates to treat serious and life-threatening medical conditions. The company's most advanced compound is ANAVEX 2-73, developed to treat Alzheimer’s disease through disease modification (i.e. could slow down, reverse or prevent Alzheimer’s disease).ANAVEX 2-73 demonstrated anti-amnesic and neuroprotective effects in pre-clinical studies conducted in France and other EU institutes.".
- Anavex_Life_Sciences label "Anavex Life Sciences".
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- Anavex_Life_Sciences sameAs Q4752398.
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- Anavex_Life_Sciences sameAs Anavex_Life_Sciences.
- Anavex_Life_Sciences wasDerivedFrom Anavex_Life_Sciences?oldid=589757799.
- Anavex_Life_Sciences homepage www.anavex.com.
- Anavex_Life_Sciences isPrimaryTopicOf Anavex_Life_Sciences.
- Anavex_Life_Sciences name "Anavex Life Sciences Corp.".