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- Antisense_therapy abstract "Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to be causative of a particular disease, it is possible to synthesize a strand of nucleic acid (DNA, RNA or a chemical analogue) that will bind to the messenger RNA (mRNA) produced by that gene and inactivate it, effectively turning that gene "off". This is because mRNA has to be single stranded for it to be translated. Alternatively, the strand might be targeted to bind a splicing site on pre-mRNA and modify the exon content of an mRNA.This synthesized nucleic acid is termed an "anti-sense" oligonucleotide because its base sequence is complementary to the gene's messenger RNA (mRNA), which is called the "sense" sequence (so that a sense segment of mRNA " 5'-AAGGUC-3' " would be blocked by the anti-sense mRNA segment " 3'-UUCCAG-5' ").Antisense drugs are being researched to treat a variety of diseases such as cancers (including lung cancer, colorectal carcinoma, pancreatic carcinoma, malignant glioma and malignant melanoma), diabetes, Amyotrophic lateral sclerosis (ALS), Duchenne muscular dystrophy and diseases such as asthma, arthritis and pouchitis with an inflammatory component. As of 2014 two antisense drugs have been approved by the U.S. Food and Drug Administration (FDA), fomivirsen (marketed as Vitravene) as a treatment for cytomegalovirus retinitis and mipomersen (marketed as Kynamro) for homozygous familial hypercholesterolemia.".
- Antisense_therapy wikiPageExternalLink f_technology.htm.
- Antisense_therapy wikiPageExternalLink basic_sci.html.
- Antisense_therapy wikiPageExternalLink medicalnews.php?newsid=74957.
- Antisense_therapy wikiPageExternalLink fomivirsen.htm.
- Antisense_therapy wikiPageID "1137144".
- Antisense_therapy wikiPageRevisionID "605300581".
- Antisense_therapy hasPhotoCollection Antisense_therapy.
- Antisense_therapy subject Category:Applied_genetics.
- Antisense_therapy subject Category:Biotechnology.
- Antisense_therapy comment "Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to be causative of a particular disease, it is possible to synthesize a strand of nucleic acid (DNA, RNA or a chemical analogue) that will bind to the messenger RNA (mRNA) produced by that gene and inactivate it, effectively turning that gene "off". This is because mRNA has to be single stranded for it to be translated.".
- Antisense_therapy label "Antisense therapy".
- Antisense_therapy label "Thérapie antisens".
- Antisense_therapy label "Антисмысловая терапия".
- Antisense_therapy label "علاج بمضادات تحسيس".
- Antisense_therapy sameAs Thérapie_antisens.
- Antisense_therapy sameAs m.049g12.
- Antisense_therapy sameAs Q4067124.
- Antisense_therapy sameAs Q4067124.
- Antisense_therapy wasDerivedFrom Antisense_therapy?oldid=605300581.
- Antisense_therapy isPrimaryTopicOf Antisense_therapy.