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- Aspartate_carbamoyltransferase abstract "Aspartate carbamoyltransferase (also known as aspartate transcarbamoylase or ATCase) catalyzes the first step in the pyrimidine biosynthetic pathway (EC 2.1.3.2).In E. coli, the enzyme is a multi-subunit protein complex composed of 12 subunits (300 kDa in total). The composition of the subunits is C6R6, forming 2 trimers of catalytic subunits (34 kDa) and 3 dimers of regulatory subunits (17 kDa). The particular arrangement of catalytic and regulatory subunits in this enzyme affords the complex with strongly allosteric behaviour with respect to its substrates. The enzyme is an archetypal example of allosteric modulation of fine control of metabolic enzyme reactions.ATCase does not follow Michaelis-Menten kinetics, but lies between the low-activity, low-affinity "tight" or T and the high-activity, high-affinity "relaxed" or R states. The binding of substrate to the catalytic subunits results in an equilibrium shift towards the R state, whereas binding of CTP to the regulatory subunits results in an equilibrium shift towards the T state. Binding of ATP to the regulatory subunits results in an equilibrium shift towards the R state.".
- Aspartate_carbamoyltransferase ecNumber "2.1.3.2".
- Aspartate_carbamoyltransferase thumbnail Apartate-carbamoyltransferase-pdb-2ATC.png?width=300.
- Aspartate_carbamoyltransferase wikiPageID "474354".
- Aspartate_carbamoyltransferase wikiPageRevisionID "590658100".
- Aspartate_carbamoyltransferase arm "p".
- Aspartate_carbamoyltransferase band "22".
- Aspartate_carbamoyltransferase caption "Aspartate carbamoyltransferase from Escherichia coli. PDB 2ATC.".
- Aspartate_carbamoyltransferase casNumber "9012".
- Aspartate_carbamoyltransferase chromosome "2".
- Aspartate_carbamoyltransferase ecNumber "2.1".
- Aspartate_carbamoyltransferase ecnumber "2.1".
- Aspartate_carbamoyltransferase entrezgene "790".
- Aspartate_carbamoyltransferase goCode "4070".
- Aspartate_carbamoyltransferase hasPhotoCollection Aspartate_carbamoyltransferase.
- Aspartate_carbamoyltransferase hgncid "1424".
- Aspartate_carbamoyltransferase iubmbEcNumber "2".
- Aspartate_carbamoyltransferase locussupplementarydata "-p21".
- Aspartate_carbamoyltransferase name "Aspartate carbamoyltransferase".
- Aspartate_carbamoyltransferase name "Human carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, dihydroorotase".
- Aspartate_carbamoyltransferase omim "114010".
- Aspartate_carbamoyltransferase refseq "NM_004341".
- Aspartate_carbamoyltransferase symbol "CAD".
- Aspartate_carbamoyltransferase uniprot "P27708".
- Aspartate_carbamoyltransferase subject Category:EC_2.1.3.
- Aspartate_carbamoyltransferase type Abstraction100002137.
- Aspartate_carbamoyltransferase type Activator114723079.
- Aspartate_carbamoyltransferase type Catalyst114723628.
- Aspartate_carbamoyltransferase type Chemical114806838.
- Aspartate_carbamoyltransferase type Compound114818238.
- Aspartate_carbamoyltransferase type Enzyme114732946.
- Aspartate_carbamoyltransferase type Macromolecule114944888.
- Aspartate_carbamoyltransferase type Material114580897.
- Aspartate_carbamoyltransferase type Matter100020827.
- Aspartate_carbamoyltransferase type Molecule114682133.
- Aspartate_carbamoyltransferase type OrganicCompound114727670.
- Aspartate_carbamoyltransferase type Part113809207.
- Aspartate_carbamoyltransferase type PhysicalEntity100001930.
- Aspartate_carbamoyltransferase type Protein114728724.
- Aspartate_carbamoyltransferase type Relation100031921.
- Aspartate_carbamoyltransferase type Substance100019613.
- Aspartate_carbamoyltransferase type Thing100002452.
- Aspartate_carbamoyltransferase type Unit109465459.
- Aspartate_carbamoyltransferase type Biomolecule.
- Aspartate_carbamoyltransferase type Enzyme.
- Aspartate_carbamoyltransferase type ProteinMolecule.
- Aspartate_carbamoyltransferase type BiologicalObject.
- Aspartate_carbamoyltransferase comment "Aspartate carbamoyltransferase (also known as aspartate transcarbamoylase or ATCase) catalyzes the first step in the pyrimidine biosynthetic pathway (EC 2.1.3.2).In E. coli, the enzyme is a multi-subunit protein complex composed of 12 subunits (300 kDa in total). The composition of the subunits is C6R6, forming 2 trimers of catalytic subunits (34 kDa) and 3 dimers of regulatory subunits (17 kDa).".
- Aspartate_carbamoyltransferase label "Aspartate carbamoyltransferase".
- Aspartate_carbamoyltransferase label "Aspartato carbammiltransferasi".
- Aspartate_carbamoyltransferase label "Karbamoilotransferaza asparaginianowa".
- Aspartate_carbamoyltransferase label "اسبارتات ناقل الكربامويل".
- Aspartate_carbamoyltransferase label "天冬氨酸转氨甲酰酶".
- Aspartate_carbamoyltransferase sameAs Aspartato_carbammiltransferasi.
- Aspartate_carbamoyltransferase sameAs Karbamoilotransferaza_asparaginianowa.
- Aspartate_carbamoyltransferase sameAs m.02dwyn.
- Aspartate_carbamoyltransferase sameAs Q656487.
- Aspartate_carbamoyltransferase sameAs Q656487.
- Aspartate_carbamoyltransferase sameAs Aspartate_carbamoyltransferase.
- Aspartate_carbamoyltransferase wasDerivedFrom Aspartate_carbamoyltransferase?oldid=590658100.
- Aspartate_carbamoyltransferase depiction Apartate-carbamoyltransferase-pdb-2ATC.png.
- Aspartate_carbamoyltransferase isPrimaryTopicOf Aspartate_carbamoyltransferase.
- Aspartate_carbamoyltransferase name "Aspartate carbamoyltransferase".