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- Aspartate_protease abstract "Aspartic proteases are a family of protease enzymes that use an aspartate residue for catalysis of their peptide substrates. In general, they have two highly conserved aspartates in the active site and are optimally active at acidic pH. Nearly all known aspartyl proteases are inhibited by pepstatin.Aspartic endopeptidases EC 3.4.23. of vertebrate, fungal and retroviral origin have been characterised. More recently, aspartic endopeptidases associated with the processing of bacterial type 4 prepilin and archaean preflagellin have been described.Eukaryotic aspartic proteases include pepsins, cathepsins, and renins. They have a two-domain structure, arising from ancestral duplication. Retroviral and retrotransposon proteases (Pfam PF00077) are much smaller and appear tobe homologous to a single domain of the eukaryotic aspartyl proteases. Each domain contributes a catalytic Asp residue, with an extended active site cleft localized between the two lobes of the molecule. One lobe has probably evolved from the other through a gene duplication event in the distant past. In modern-day enzymes, although the three-dimensional structures are very similar, the amino acid sequences are more divergent, except for the catalytic site motif, which is very conserved. The presence and position of disulfide bridges are other conserved features of aspartic peptidases.".
- Aspartate_protease symbol "A1_Propeptide".
- Aspartate_protease symbol "Asp".
- Aspartate_protease thumbnail PDB_1lyb_EBI.jpg?width=300.
- Aspartate_protease wikiPageExternalLink A.
- Aspartate_protease wikiPageExternalLink famsum?family=A1.
- Aspartate_protease wikiPageID "7748624".
- Aspartate_protease wikiPageRevisionID "590658110".
- Aspartate_protease caption "Structures of native and inhibited forms of human cathepsin D.".
- Aspartate_protease caption "crystal and molecular structures of human progastricsin at 1.62 angstroms resolution".
- Aspartate_protease hasPhotoCollection Aspartate_protease.
- Aspartate_protease interpro "IPR001461".
- Aspartate_protease interpro "IPR012848".
- Aspartate_protease name "A1_Propeptide".
- Aspartate_protease name "Eukaryotic aspartyl protease".
- Aspartate_protease opmFamily "108".
- Aspartate_protease opmProtein "1".
- Aspartate_protease pfam "PF00026".
- Aspartate_protease pfam "PF07966".
- Aspartate_protease prosite "PDOC00128".
- Aspartate_protease scop "1".
- Aspartate_protease symbol "A1_Propeptide".
- Aspartate_protease symbol "Asp".
- Aspartate_protease subject Category:Peripheral_membrane_proteins.
- Aspartate_protease subject Category:Protein_domains.
- Aspartate_protease subject Category:Protein_families.
- Aspartate_protease type Abstraction100002137.
- Aspartate_protease type Attribute100024264.
- Aspartate_protease type Chemical114806838.
- Aspartate_protease type Compound114818238.
- Aspartate_protease type Environment113934596.
- Aspartate_protease type Macromolecule114944888.
- Aspartate_protease type Material114580897.
- Aspartate_protease type Matter100020827.
- Aspartate_protease type Molecule114682133.
- Aspartate_protease type OrganicCompound114727670.
- Aspartate_protease type Part113809207.
- Aspartate_protease type PeripheralMembraneProteins.
- Aspartate_protease type PhysicalEntity100001930.
- Aspartate_protease type Protein114728724.
- Aspartate_protease type ProteinDomains.
- Aspartate_protease type Relation100031921.
- Aspartate_protease type Situation113927383.
- Aspartate_protease type Sphere114514039.
- Aspartate_protease type State100024720.
- Aspartate_protease type Substance100019613.
- Aspartate_protease type Thing100002452.
- Aspartate_protease type Unit109465459.
- Aspartate_protease type Biomolecule.
- Aspartate_protease type Protein.
- Aspartate_protease type BiologicalObject.
- Aspartate_protease comment "Aspartic proteases are a family of protease enzymes that use an aspartate residue for catalysis of their peptide substrates. In general, they have two highly conserved aspartates in the active site and are optimally active at acidic pH. Nearly all known aspartyl proteases are inhibited by pepstatin.Aspartic endopeptidases EC 3.4.23. of vertebrate, fungal and retroviral origin have been characterised.".
- Aspartate_protease label "Aspartate protease".
- Aspartate_protease label "Aspartatproteasen".
- Aspartate_protease label "Protéase aspartique".
- Aspartate_protease sameAs Aspartatproteasen.
- Aspartate_protease sameAs Protéase_aspartique.
- Aspartate_protease sameAs Aspartat_protease.
- Aspartate_protease sameAs m.026brrv.
- Aspartate_protease sameAs Q410111.
- Aspartate_protease sameAs Q410111.
- Aspartate_protease sameAs Aspartate_protease.
- Aspartate_protease wasDerivedFrom Aspartate_protease?oldid=590658110.
- Aspartate_protease depiction PDB_1lyb_EBI.jpg.
- Aspartate_protease isPrimaryTopicOf Aspartate_protease.