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- Astacin abstract "In molecular biology, astacin is a family of metallopeptidases. These metallopeptidases belong to the MEROPS peptidase family M12, subfamily M12A (astacin family, clan MA(M)). The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA and the predicted active site residues for members of this family and thermolysin occur in the motif HEXXH.The astacin family of metalloendopeptidases (EC 3.4.24.21) encompasses a range of proteins found in hydra to humans, in mature and developmental systems. Their functions include activation of growth factors, degradation of polypeptides, and processing of extracellular proteins. The proteins are synthesised with N-terminal signal and pro-enzyme sequences, and many contain multiple domains C-terminal to the protease domain. They are either secreted from cells, or are associated with the plasma membrane.The astacin molecule adopts a kidney shape, with a deep active-site cleft between its N- and C-terminal domains. The zinc ion, which lies at the bottom of the cleft, exhibits a unique penta-coordinated mode of binding, involving 3 histidine residues, a tyrosine and a water molecule (which is also bound to the carboxylate side chain of Glu93). The N-terminal domain comprises 2 alpha-helices and a 5-stranded beta-sheet. The overall topology of this domain is shared by the archetypal zinc-endopeptidase thermolysin. Astacin protease domains also share common features with serralysins, matrix metalloendopeptidases, and snake venom proteases; they cleave peptide bonds in polypeptides such as insulin B chain and bradykinin, and in proteins such as casein and gelatin; and they have arylamidase activity.".
- Astacin symbol "Astacin".
- Astacin thumbnail PDB_1qjj_EBI.jpg?width=300.
- Astacin wikiPageExternalLink famsum?family=m12.
- Astacin wikiPageID "32149517".
- Astacin wikiPageRevisionID "590659608".
- Astacin caption "structure of astacin with a hydroxamic acid inhibitor".
- Astacin casNumber "143179".
- Astacin ecNumber "3.4".
- Astacin goCode "8533".
- Astacin hasPhotoCollection Astacin.
- Astacin interpro "IPR001506".
- Astacin iubmbEcNumber "3".
- Astacin merops "M12".
- Astacin name "Astacin".
- Astacin name "astacin".
- Astacin pfam "PF01400".
- Astacin pfamClan "CL0126".
- Astacin prosite "PDOC00129".
- Astacin scop "1".
- Astacin symbol "Astacin".
- Astacin subject Category:Protein_domains.
- Astacin type Abstraction100002137.
- Astacin type Attribute100024264.
- Astacin type Environment113934596.
- Astacin type ProteinDomains.
- Astacin type Situation113927383.
- Astacin type Sphere114514039.
- Astacin type State100024720.
- Astacin type Biomolecule.
- Astacin type Protein.
- Astacin type BiologicalObject.
- Astacin comment "In molecular biology, astacin is a family of metallopeptidases. These metallopeptidases belong to the MEROPS peptidase family M12, subfamily M12A (astacin family, clan MA(M)).".
- Astacin label "Astacin".
- Astacin sameAs m.0gx0n46.
- Astacin sameAs Q4810499.
- Astacin sameAs Q4810499.
- Astacin sameAs 2456.
- Astacin sameAs Astacin.
- Astacin wasDerivedFrom Astacin?oldid=590659608.
- Astacin depiction PDB_1qjj_EBI.jpg.
- Astacin isPrimaryTopicOf Astacin.