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- Atherosclerosis abstract "Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of the accumulation of calcium and fatty materials such as cholesterol and triglyceride. It reduces the elasticity of the artery walls and therefore allows less blood to travel through. This also increases blood pressure. It is a syndrome affecting arterial blood vessels, a chronic inflammatory response in the walls of arteries, caused largely by the accumulation of macrophages and white blood cells and promoted by low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high-density lipoproteins (HDL) (see apoA-1 Milano). It is commonly referred to as a hardening or furring of the arteries. It is caused by the formation of multiple atheromatous plaques within the arteries. The plaque is divided into three distinct components: The atheroma ("lump of gruel", from Greek ἀθήρα (athera), meaning "gruel"), which is the nodular accumulation of a soft, flaky, yellowish material at the center of large plaques, composed of macrophages nearest the lumen of the artery Underlying areas of cholesterol crystals Calcification at the outer base of older/more advanced lesions.The following terms are similar, yet distinct, in both spelling and meaning, and can be easily confused: arteriosclerosis, arteriolosclerosis, and atherosclerosis. Arteriosclerosis is a general term describing any hardening (and loss of elasticity) of medium or large arteries (from Greek ἀρτηρία (artēria), meaning "artery", and σκλήρωσις (sklerosis), meaning "hardening"); arteriolosclerosis is any hardening (and loss of elasticity) of arterioles (small arteries); atherosclerosis is a hardening of an artery specifically due to an atheromatous plaque. The term atherogenic is used for substances or processes that cause atherosclerosis.[citation needed]Atherosclerosis is a chronic disease that remains asymptomatic for decades. Atherosclerotic lesions, or atherosclerotic plaques are separated into two broad categories: Stable and unstable (also called vulnerable). The pathobiology of atherosclerotic lesions is very complicated but generally, stable atherosclerotic plaques, which tend to be asymptomatic, are rich in extracellular matrix and smooth muscle cells, while, unstable plaques are rich in macrophages and foam cells and the extracellular matrix separating the lesion from the arterial lumen (also known as the fibrous cap) is usually weak and prone to rupture. Ruptures of the fibrous cap expose thrombogenic material, such as collagen to the circulation and eventually induce thrombus formation in the lumen. Upon formation, intraluminal thrombi can occlude arteries outright (e.g. coronary occlusion), but more often they detach, move into the circulation and eventually occluding smaller downstream branches causing thromboembolism. Apart from thromboembolism, chronically expanding atherosclerotic lesions can cause complete closure of the lumen. Interestingly, chronically expanding lesions are often asymptomatic until lumen stenosis is so severe (usually over 80%) that blood supply to downstream tissue(s) is insufficient, resulting in ischemia.These complications of advanced atherosclerosis are chronic, slowly progressive and cumulative. Most commonly, soft plaque suddenly ruptures (see vulnerable plaque), causing the formation of a thrombus that will rapidly slow or stop blood flow, leading to death of the tissues fed by the artery in approximately 5 minutes. This catastrophic event is called an infarction. One of the most common recognized scenarios is called coronary thrombosis of a coronary artery, causing myocardial infarction (a heart attack). The same process in an artery to the brain is commonly called stroke. Another common scenario in very advanced disease is claudication from insufficient blood supply to the legs. Atherosclerosis affects the entire artery tree, but mostly larger, high-pressure vessels such as the coronary, renal, femoral, cerebral, and carotid arteries. These are termed "clinically silent" because the person having the infarction does not notice the problem and does not seek medical help, or when they do, physicians do not recognize what has happened.".
- Atherosclerosis diseasesdb "1039".
- Atherosclerosis emedicineSubject "med".
- Atherosclerosis emedicineTopic "182".
- Atherosclerosis icd10 "I70".
- Atherosclerosis icd9 "440, 414.0".
- Atherosclerosis medlineplus "000171".
- Atherosclerosis meshId "D050197".
- Atherosclerosis thumbnail Endo_dysfunction_Athero.PNG?width=300.
- Atherosclerosis wikiPageExternalLink review-article-hypertension-and-pathogenesis-of-atherosclerosis.
- Atherosclerosis wikiPageExternalLink Home.aspx.
- Atherosclerosis wikiPageID "85385".
- Atherosclerosis wikiPageRevisionID "606447653".
- Atherosclerosis caption "The progression of atherosclerosis".
- Atherosclerosis diseasesdb "1039".
- Atherosclerosis emedicinesubj "med".
- Atherosclerosis emedicinetopic "182".
- Atherosclerosis hasPhotoCollection Atherosclerosis.
- Atherosclerosis icd "440414".
- Atherosclerosis icd "I70".
- Atherosclerosis medlineplus "171".
- Atherosclerosis meshid "D050197".
- Atherosclerosis name "Atherosclerosis".
- Atherosclerosis wordnet_type synset-disease-noun-1.
- Atherosclerosis subject Category:Diseases_of_arteries,_arterioles_and_capillaries.
- Atherosclerosis subject Category:Inflammations.
- Atherosclerosis subject Category:Medical_conditions_related_to_obesity.
- Atherosclerosis subject Category:Vascular_diseases.
- Atherosclerosis type Disease.
- Atherosclerosis type AilmentCondition.
- Atherosclerosis type Situation.
- Atherosclerosis comment "Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of the accumulation of calcium and fatty materials such as cholesterol and triglyceride. It reduces the elasticity of the artery walls and therefore allows less blood to travel through. This also increases blood pressure.".
- Atherosclerosis label "Ateroesclerosis".
- Atherosclerosis label "Aterosclerose".
- Atherosclerosis label "Aterosclerosi".
- Atherosclerosis label "Atheromatose".
- Atherosclerosis label "Atherosclerosis".
- Atherosclerosis label "Miażdżyca".
- Atherosclerosis label "Атеросклероз".
- Atherosclerosis label "تصلب عصيدي".
- Atherosclerosis label "动脉粥样硬化".
- Atherosclerosis sameAs Ateroesclerosis.
- Atherosclerosis sameAs Aterosklerosis.
- Atherosclerosis sameAs Aterosclerosi.
- Atherosclerosis sameAs Atheromatose.
- Atherosclerosis sameAs Miażdżyca.
- Atherosclerosis sameAs Aterosclerose.
- Atherosclerosis sameAs m.0lp66.
- Atherosclerosis sameAs Q13380381.
- Atherosclerosis sameAs Q13380381.
- Atherosclerosis sameAs 121.
- Atherosclerosis sameAs C0003850.
- Atherosclerosis sameAs C0004153.
- Atherosclerosis sameAs C0010054.
- Atherosclerosis wasDerivedFrom Atherosclerosis?oldid=606447653.
- Atherosclerosis depiction Endo_dysfunction_Athero.PNG.
- Atherosclerosis isPrimaryTopicOf Atherosclerosis.
- Atherosclerosis name "Atherosclerosis".