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- Autoimmune_regulator abstract "The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. AIRE is a transcription factor expressed in the medulla of the thymus and controls the mechanism that prevents the immune system from attacking the body itself.Each T cell attacks a foreign substance presented within a MHC molecule which it identifies with its receptor. T cells have receptors which are generated by randomly shuffling gene segments. Each T cell attacks a different substance. T cells that attack the body's own proteins are eliminated in the thymus. Medullary thymic epithelial cells (mTECs) express major proteins from elsewhere in the body (so called "tissue-specific self-antigens" - TSAs), and T cells that respond to those proteins are eliminated through cell death(apoptosis), thus it is thought that AIRE therefore drives negative selection.The AIRE controls the expression of those thymic epithelial cells in the medulla (inner part) of the thymus. When AIRE is defective, T cells can attack the body, resulting in autoimmune disease.".
- Autoimmune_regulator entrezgene "326".
- Autoimmune_regulator wikiPageID "7908811".
- Autoimmune_regulator wikiPageRevisionID "590720734".
- Autoimmune_regulator hasPhotoCollection Autoimmune_regulator.
- Autoimmune_regulator subject Category:Immune_system.
- Autoimmune_regulator subject Category:Immunology.
- Autoimmune_regulator subject Category:Transcription_factors.
- Autoimmune_regulator subject Category:WikiProject_Molecular_and_Cellular_Biology_articles.
- Autoimmune_regulator type Abstraction100002137.
- Autoimmune_regulator type Beginning107290905.
- Autoimmune_regulator type Cause107326557.
- Autoimmune_regulator type Event100029378.
- Autoimmune_regulator type Factor107327805.
- Autoimmune_regulator type Happening107283608.
- Autoimmune_regulator type Origin107323922.
- Autoimmune_regulator type PsychologicalFeature100023100.
- Autoimmune_regulator type TranscriptionFactors.
- Autoimmune_regulator type YagoPermanentlyLocatedEntity.
- Autoimmune_regulator type Biomolecule.
- Autoimmune_regulator type Protein.
- Autoimmune_regulator type BiologicalObject.
- Autoimmune_regulator comment "The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. AIRE is a transcription factor expressed in the medulla of the thymus and controls the mechanism that prevents the immune system from attacking the body itself.Each T cell attacks a foreign substance presented within a MHC molecule which it identifies with its receptor. T cells have receptors which are generated by randomly shuffling gene segments. Each T cell attacks a different substance.".
- Autoimmune_regulator label "Autoimmune regulator".
- Autoimmune_regulator label "Regulador autoinmune".
- Autoimmune_regulator sameAs Regulador_autoinmune.
- Autoimmune_regulator sameAs m.026jnln.
- Autoimmune_regulator sameAs Q4826349.
- Autoimmune_regulator sameAs Q4826349.
- Autoimmune_regulator sameAs AIRE.
- Autoimmune_regulator sameAs Autoimmune_regulator.
- Autoimmune_regulator wasDerivedFrom Autoimmune_regulator?oldid=590720734.
- Autoimmune_regulator isPrimaryTopicOf Autoimmune_regulator.