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- B-box_zinc_finger abstract "In molecular biology the B-box-type zinc finger domain is a short protein domain of around 40 amino acid residues in length. B-box zinc fingers can be divided into two groups, where types 1 and 2 B-box domains differ in their consensus sequence and in the spacing of the 7-8 zinc-binding residues. Several proteins contain both types 1 and 2 B-boxes, suggesting some level of cooperativity between these two domains. B-box domains are found in over 1500 proteins from a variety of organisms. They are found in TRIM (tripartite motif) proteins that consist of an N-terminal RING finger (originally called an A-box), followed by 1-2 B-box domains and a coiled-coil domain (also called RBCC for Ring, B-box, Coiled-Coil). TRIM proteins contain a type 2 B-box domain, and may also contain a type 1 B-box. In proteins that do not contain RING or coiled-coil domains, the B-box domain is primarily type 2. Many type 2 B-box proteins are involved in ubiquitinylation. Proteins containing a B-box zinc finger domain include transcription factors, ribonucleoproteins and proto-oncoproteins; for example, MID1, MID2, TRIM9, TNL, TRIM36, TRIM63, TRIFIC, NCL1 and CONSTANS-like proteins.The microtubule-associated E3 ligase MID1 (EC) contains a type 1 B-box zinc finger domain. MID1 specifically binds Alpha-4, which in turn recruits the catalytic subunit of phosphatase 2A (PP2Ac). This complex is required for targeting of PP2Ac for proteasome-mediated degradation. The MID1 B-box coordinates two zinc ions and adopts a beta/beta/alpha cross-brace structure similar to that of ZZ, PHD, RING and FYVE zinc fingers.Prokaryotic homologs of the domain are present in several bacterial lineages and methanogenic archaea, and often show fusions to peptidase domains such as the rhomboid-like serine peptidase, and Zn-dependent metallopeptidase. Other versions typically contain transmembrane helices and might also show fusions to domains such as DNAJ, FHA, SH3, WD40 and tetratricopeptide repeats. Together these associations suggest a role for the prokaryotic homologs of the B-box zinc finger domain in proteolytic processing, folding or stability of membrane-associated proteins. The domain architectural syntax is remarkably similar to that seen in prokaryotic homologs of the AN1 zinc finger and LIM domains.".
- B-box_zinc_finger symbol "zf-B_box".
- B-box_zinc_finger thumbnail PDB_1fre_EBI.jpg?width=300.
- B-box_zinc_finger wikiPageExternalLink 6.3.2.
- B-box_zinc_finger wikiPageExternalLink planttfdb.cbi.pku.edu.cn.
- B-box_zinc_finger wikiPageExternalLink family.php?fam=CO-like.
- B-box_zinc_finger wikiPageExternalLink family.php?fam=DBB.
- B-box_zinc_finger wikiPageID "32009646".
- B-box_zinc_finger wikiPageRevisionID "590725619".
- B-box_zinc_finger caption "Structure of the xnf7 B-box, developmental protein".
- B-box_zinc_finger hasPhotoCollection B-box_zinc_finger.
- B-box_zinc_finger interpro "IPR000315".
- B-box_zinc_finger name "zf-B_box".
- B-box_zinc_finger pfam "PF00643".
- B-box_zinc_finger prosite "PDOC50015".
- B-box_zinc_finger scop "1".
- B-box_zinc_finger symbol "zf-B_box".
- B-box_zinc_finger subject Category:Protein_domains.
- B-box_zinc_finger type Abstraction100002137.
- B-box_zinc_finger type Attribute100024264.
- B-box_zinc_finger type Environment113934596.
- B-box_zinc_finger type ProteinDomains.
- B-box_zinc_finger type Situation113927383.
- B-box_zinc_finger type Sphere114514039.
- B-box_zinc_finger type State100024720.
- B-box_zinc_finger type Biomolecule.
- B-box_zinc_finger type Protein.
- B-box_zinc_finger type BiologicalObject.
- B-box_zinc_finger comment "In molecular biology the B-box-type zinc finger domain is a short protein domain of around 40 amino acid residues in length. B-box zinc fingers can be divided into two groups, where types 1 and 2 B-box domains differ in their consensus sequence and in the spacing of the 7-8 zinc-binding residues. Several proteins contain both types 1 and 2 B-boxes, suggesting some level of cooperativity between these two domains. B-box domains are found in over 1500 proteins from a variety of organisms.".
- B-box_zinc_finger label "B-box zinc finger".
- B-box_zinc_finger sameAs m.0gx2sjr.
- B-box_zinc_finger sameAs Q4833716.
- B-box_zinc_finger sameAs Q4833716.
- B-box_zinc_finger sameAs B-box_zinc_finger.
- B-box_zinc_finger wasDerivedFrom B-box_zinc_finger?oldid=590725619.
- B-box_zinc_finger depiction PDB_1fre_EBI.jpg.
- B-box_zinc_finger isPrimaryTopicOf B-box_zinc_finger.