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- BACE1-AS abstract "BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease. BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.Knocking down BACE1-AS reduces amyloid production and plaque deposition.".
- BACE1-AS wikiPageID "32549551".
- BACE1-AS wikiPageRevisionID "566670109".
- BACE1-AS chromosome "11".
- BACE1-AS entrezchromosome "AP000892.4".
- BACE1-AS entrezgene "100379571".
- BACE1-AS genlocEnd "90625".
- BACE1-AS genlocStart "89828".
- BACE1-AS hasPhotoCollection BACE1-AS.
- BACE1-AS name "BACE1 antisense RNA".
- BACE1-AS organism "human".
- BACE1-AS refseqmrna "NR_037803".
- BACE1-AS symbol "BACE1-AS".
- BACE1-AS taxid "9606".
- BACE1-AS subject Category:Alzheimer's_disease.
- BACE1-AS subject Category:Human_genes.
- BACE1-AS subject Category:Non-coding_RNA.
- BACE1-AS subject Category:RNA.
- BACE1-AS comment "BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease. BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism.".
- BACE1-AS label "BACE1-AS".
- BACE1-AS sameAs m.0h1cc_m.
- BACE1-AS sameAs Q4834493.
- BACE1-AS sameAs Q4834493.
- BACE1-AS wasDerivedFrom BACE1-AS?oldid=566670109.
- BACE1-AS isPrimaryTopicOf BACE1-AS.