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- B_cell abstract "B cells or B lymphocytes are a type of lymphocyte in the humoral immunity of the adaptive immune system. B cells can be distinguished from other lymphocytes, such as T cells and natural killer cells (NK cells), by the presence of a protein on the B cells outer surface known as a B cell receptor (BCR). This specialized receptor protein allows a B cell to bind to a specific antigen. In birds, B cells mature in the bursa of Fabricius. In mammals, immature B cells are formed in the bone marrow.The principal functions of B cells are to make antibodies against antigens, to perform the role of antigen-presenting cells (APCs), and to develop into memory B cells after activation by antigen interaction. Recently, a new, suppressive function of B cells has been discovered.B cell development occurs through several stages, each stage representing a change in the genome content at the antibody loci. An antibody is composed of two identical light (L) and two identical heavy (H) chains, and the genes specifying them are found in the 'V' (Variable) region and the 'C' (Constant) region. In the heavy-chain 'V' region there are three segments; V, D, and J, which recombine randomly, in a process called VDJ recombination, to produce a unique variable domain in the immunoglobulin of each individual B cell. Similar rearrangements occur for light-chain 'V' region except there are only two segments involved: V and J. The list below describes the process of immunoglobulin formation at the different stages of B cell development.When the B cell fails in any step of the maturation process, it will die by a mechanism called apoptosis, here called clonal deletion. B cells are continuously produced in the bone marrow. When the B cell receptor, on the surface of the cell, matches the detected antigens present in the body, the B cell proliferates and secretes a free form of those receptors (antibodies) with identical binding sites as the ones on the original cell surface. After activation, the cell proliferates and B memory cells would form to recognise the same antigen. This information would then be used as a part of the adaptive immune system for a more efficient and more powerful immune response for future encounters with that antigen.B cell membrane receptors evolve and change throughout the B cell lifespan. The proteins TACI, BCMA, and BAFF-R (B cell-activating factor receptor) are present on both immature B cells and mature B cells. Belimumab is a monoclonal inhibitor of the soluble form of B cell-activating factor (BAFF), whereas blisibimod is an inhibitor of both membrane and soluble forms of BAFF. CD20 is expressed on all stages of B cell development except the first and last; it is present from pre-B cells through memory cells, but not on either pre-pro-B cells or plasma cells.".
- B_cell thumbnail Original_antigenic_sin.svg?width=300.
- B_cell wikiPageExternalLink ?p=2357.
- B_cell wikiPageExternalLink B_and_Tcells.html.
- B_cell wikiPageExternalLink Bcellmat.html.
- B_cell wikiPageExternalLink GODfigs.htm.
- B_cell wikiPageExternalLink Biology_of_immunoglobulin_light_chains.
- B_cell wikiPageID "211941".
- B_cell wikiPageRevisionID "600276763".
- B_cell caption "The cells of the immune system that make antibodies to invading pathogens such as viruses. They form memory cells that remember the same pathogen for faster antibody production in future infections.".
- B_cell hasPhotoCollection B_cell.
- B_cell latin "lymphocytus B".
- B_cell name "B cell".
- B_cell subject Category:Human_cells.
- B_cell subject Category:Lymphocytes.
- B_cell type Abstraction100002137.
- B_cell type Anatomy106057539.
- B_cell type Biology106037666.
- B_cell type Cognition100023271.
- B_cell type Content105809192.
- B_cell type Discipline105996646.
- B_cell type KnowledgeDomain105999266.
- B_cell type LifeScience106037298.
- B_cell type Morphology106078327.
- B_cell type NaturalScience106000400.
- B_cell type PsychologicalFeature100023100.
- B_cell type Science105999797.
- B_cell type AnatomicalStructure.
- B_cell type BiologicalObject.
- B_cell comment "B cells or B lymphocytes are a type of lymphocyte in the humoral immunity of the adaptive immune system. B cells can be distinguished from other lymphocytes, such as T cells and natural killer cells (NK cells), by the presence of a protein on the B cells outer surface known as a B cell receptor (BCR). This specialized receptor protein allows a B cell to bind to a specific antigen. In birds, B cells mature in the bursa of Fabricius.".
- B_cell label "B cell".
- B_cell label "B-Lymphozyt".
- B_cell label "B-cel".
- B_cell label "B-лимфоциты".
- B_cell label "B細胞".
- B_cell label "B细胞".
- B_cell label "Limfocyt B".
- B_cell label "Linfocita B".
- B_cell label "Linfocito B".
- B_cell label "Linfócito B".
- B_cell label "Lymphocyte B".
- B_cell label "خلية بائية".
- B_cell sameAs B-lymfocyt.
- B_cell sameAs B-Lymphozyt.
- B_cell sameAs Linfocito_B.
- B_cell sameAs Lymphocyte_B.
- B_cell sameAs Sel_B.
- B_cell sameAs Linfocita_B.
- B_cell sameAs B細胞.
- B_cell sameAs B세포.
- B_cell sameAs B-cel.
- B_cell sameAs Limfocyt_B.
- B_cell sameAs Linfócito_B.
- B_cell sameAs m.01f1w5.
- B_cell sameAs Q188930.
- B_cell sameAs Q188930.
- B_cell sameAs B_cell.
- B_cell wasDerivedFrom B_cell?oldid=600276763.
- B_cell depiction Original_antigenic_sin.svg.
- B_cell isPrimaryTopicOf B_cell.
- B_cell name "B cell".