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- BamHI abstract "BamHI (from Bacillus amyloliquefaciens) is a type II restriction endonuclease, having the capacity for recognizing short sequences (6 b.p.) of DNA and specifically cleaving them at a target site. This exhibit focuses on the structure-function relations of BamHI as described by Newman, et al. (1995). BamHI binds at the recognition sequence 5'-GGATCC-3', and cleaves these sequences just after the 5'-guanine on each strand. This cleavage results in sticky ends which are 4 b.p. long. In its unbound form, BamHI displays a central b sheet, which resides in between a helices. BamHI is an extraordinarily unique molecule in that it undergoes a series of unconventional conformational changes upon DNA recognition. This allows the DNA to maintain its normal B-DNA conformation without distorting to facilitate enzyme binding. BamHI is a symmetric dimer. DNA is bound in a large cleft that is formed between dimers; the enzyme binds in a "crossover" manner. Each BamHI subunit makes the majority of its backbone contacts with the phosphates of a DNA half site but base pair contacts are made between each BamHI subunit and nitrogenous bases in the major groove of the opposite DNA half site. The protein binds the bases through either direct hydrogen bonds or water-mediated H-bonds between the protein and every H-bond donor/acceptor group in the major groove. Major groove contacts are formed by atoms residing on the amino-terminus of a parallel 4 helix bundle. This bundle marks the BamHI dimer interface, and it is thought that the dipole moments of the NH2-terminal atoms on this bundle may contribute to electrostatic stabilization.".
- BamHI symbol "BamHI".
- BamHI thumbnail PDB_1esg_EBI.jpg?width=300.
- BamHI wikiPageExternalLink ?Uniprot_accession=P23940.
- BamHI wikiPageID "10388309".
- BamHI wikiPageRevisionID "580723187".
- BamHI caption "restriction endonuclease BamHI bound to a non-specific dna.".
- BamHI hasPhotoCollection BamHI.
- BamHI interpro "IPR004194".
- BamHI name "BamHI".
- BamHI pfam "PF02923".
- BamHI pfamClan "CL0236".
- BamHI scop "1".
- BamHI symbol "BamHI".
- BamHI subject Category:Biotechnology.
- BamHI subject Category:Molecular_biology.
- BamHI subject Category:Restriction_enzymes.
- BamHI type Abstraction100002137.
- BamHI type Activator114723079.
- BamHI type Catalyst114723628.
- BamHI type Chemical114806838.
- BamHI type Compound114818238.
- BamHI type Endonuclease114605415.
- BamHI type Enzyme114732946.
- BamHI type Macromolecule114944888.
- BamHI type Material114580897.
- BamHI type Matter100020827.
- BamHI type Molecule114682133.
- BamHI type Nuclease114963916.
- BamHI type OrganicCompound114727670.
- BamHI type Part113809207.
- BamHI type PhysicalEntity100001930.
- BamHI type Protein114728724.
- BamHI type Relation100031921.
- BamHI type RestrictionEndonuclease115005071.
- BamHI type RestrictionEnzymes.
- BamHI type Substance100019613.
- BamHI type Thing100002452.
- BamHI type Unit109465459.
- BamHI type Biomolecule.
- BamHI type Protein.
- BamHI type BiologicalObject.
- BamHI comment "BamHI (from Bacillus amyloliquefaciens) is a type II restriction endonuclease, having the capacity for recognizing short sequences (6 b.p.) of DNA and specifically cleaving them at a target site. This exhibit focuses on the structure-function relations of BamHI as described by Newman, et al. (1995). BamHI binds at the recognition sequence 5'-GGATCC-3', and cleaves these sequences just after the 5'-guanine on each strand. This cleavage results in sticky ends which are 4 b.p. long.".
- BamHI label "BamHI".
- BamHI label "BamHI".
- BamHI label "BamHI".
- BamHI label "BamHI".
- BamHI label "إنزيم BamHI".
- BamHI sameAs BamHI.
- BamHI sameAs BamHI.
- BamHI sameAs BamHI.
- BamHI sameAs BamHI.
- BamHI sameAs m.02qb7cc.
- BamHI sameAs Q409191.
- BamHI sameAs Q409191.
- BamHI sameAs BamHI.
- BamHI wasDerivedFrom BamHI?oldid=580723187.
- BamHI depiction PDB_1esg_EBI.jpg.
- BamHI isPrimaryTopicOf BamHI.