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- Barbiturate_overdose abstract "A barbiturate overdose results when a person takes a larger-than-prescribed dose of barbiturates. Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness, shallow breathing, and staggering. In severe cases, coma and death can result. The lethal dosage of barbiturates varies greatly with tolerance and from one individual to another.Barbiturate overdose with other CNS (central nervous system) depressants, such as alcohol, opiates or benzodiazepines, is even more dangerous due to additive CNS and respiratory depressant effects. In the case of benzodiazepines, barbiturates also increase the binding affinity of the benzodiazepine binding sites thus leading to an exaggerated effect of benzodiazepines. This makes the predicting the effect of combinations difficult and the same dose of the same drugs will not always produce the same degree of sedation and respiratory depression as the previous experience.Benzodiazepines increase the frequency of chloride channel opening while barbiturates increase the duration that the chloride pore remains open. If a normal pore opened once every 30 seconds to pass one chloride ion, a benzodiazepine may cause it to open once every ten seconds while a barbiturate may cause it to remain open until three ions have passed through. Separately, both of these increase the effect of the pore threefold, but together, the channel would allow three ions to pass every 10 seconds. This would exponentially increase the effect of the pore ninefold, greater than the sum of the two drugs effects.The treatment of barbiturate abuse or overdose is generally supportive. The amount of support required depends on the person's symptoms. If the patient is drowsy but awake and can swallow and breathe without difficulty, the treatment can be as simple as monitoring the patient closely. If the patient is not breathing, it may involve mechanical ventilation until the drug has worn off.Supportive treatment often includes the following: Activated charcoal may be given via nasogastric tube. Intravenous administration of saline, naloxone, thiamine, and/or glucose. NaHCO3 to alkalize the urine to increase rate of excretion. Observation in the Emergency Department for a number of hours or admission to the hospital for several days of observation if symptoms are severe. Advise the patient about drug misuse or refer for psychiatric consult.In famous cases, Marilyn Monroe, Dalida, Judy Garland, and Jimi Hendrix died from a barbiturate overdose.".
- Barbiturate_overdose emedicineSubject "article".
- Barbiturate_overdose emedicineTopic "813155".
- Barbiturate_overdose icd10 "F13.0, T42.3".
- Barbiturate_overdose icd9 "969".
- Barbiturate_overdose wikiPageID "26983645".
- Barbiturate_overdose wikiPageRevisionID "597931006".
- Barbiturate_overdose emedicinesubj "article".
- Barbiturate_overdose emedicinetopic "813155".
- Barbiturate_overdose hasPhotoCollection Barbiturate_overdose.
- Barbiturate_overdose icd "969".
- Barbiturate_overdose icd "F13.0, T42.3".
- Barbiturate_overdose name "Barbiturate overdose".
- Barbiturate_overdose subject Category:Barbiturates.
- Barbiturate_overdose subject Category:Poisoning_by_drugs,_medicaments_and_biological_substances.
- Barbiturate_overdose type Abstraction100002137.
- Barbiturate_overdose type Attribute100024264.
- Barbiturate_overdose type Condition113920835.
- Barbiturate_overdose type Disease114070360.
- Barbiturate_overdose type IllHealth114052046.
- Barbiturate_overdose type Illness114061805.
- Barbiturate_overdose type PathologicalState114051917.
- Barbiturate_overdose type PhysicalCondition114034177.
- Barbiturate_overdose type State100024720.
- Barbiturate_overdose type Disease.
- Barbiturate_overdose type Situation.
- Barbiturate_overdose comment "A barbiturate overdose results when a person takes a larger-than-prescribed dose of barbiturates. Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness, shallow breathing, and staggering. In severe cases, coma and death can result.".
- Barbiturate_overdose label "Barbiturate overdose".
- Barbiturate_overdose label "Intossicazione da barbiturici".
- Barbiturate_overdose label "バルビツール酸系過量服薬".
- Barbiturate_overdose sameAs Intossicazione_da_barbiturici.
- Barbiturate_overdose sameAs バルビツール酸系過量服薬.
- Barbiturate_overdose sameAs m.0bwj2gf.
- Barbiturate_overdose sameAs Q1184752.
- Barbiturate_overdose sameAs Q1184752.
- Barbiturate_overdose sameAs Barbiturate_overdose.
- Barbiturate_overdose wasDerivedFrom Barbiturate_overdose?oldid=597931006.
- Barbiturate_overdose isPrimaryTopicOf Barbiturate_overdose.
- Barbiturate_overdose name "Barbiturate overdose".