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- Belimumab abstract "Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). B cells are responsible for part of the normal immune response, and also for the over-aggressive immune response in autoimmune diseases like systemic lupus erythematosus (SLE).Belimumab is approved in the United States, Canada and Europe for treatment of SLE. However, the major phase III trials excluded the more severe cases of SLE with kidney and brain damage, so its effectiveness has not been demonstrated in those cases. A Phase III study for SLE patients with kidney disease is now recruiting.U.S. F.D.A. reviewers were concerned that belimumab is only "marginally" effective, and that there were more deaths in the treatment group.Belimumab's defenders said that in addition to its modest efficiency, belimumab allowed patients to significantly reduce their use of corticosteroids.Belimumab is expensive, typically $28,000 for the first year. The UK National Institute for Health and Care Excellence (NICE) calculated the cost of belimumab at £61,200 per quality adjusted life year (QALY), which is more than the normally accepted £20,000 to £30,000.Phase II trials of belimumab for rheumatoid arthritis were unsuccessful. Phase II trials for Sjögren’s Syndrome were more successful.Belimumab was developed by Human Genome Sciences (HGS) and Cambridge Antibody Technology. GlaxoSmithKline acquired HGS, took belimumab through Phase III clinical trials, and markets belimumab.".
- Belimumab atcPrefix "L04".
- Belimumab atcSuffix "AA26".
- Belimumab casNumber "356547-88-1".
- Belimumab fdaUniiCode "73B0K5S26A".
- Belimumab wikiPageID "9124243".
- Belimumab wikiPageRevisionID "603979007".
- Belimumab atcPrefix "L04".
- Belimumab atcSuffix "AA26".
- Belimumab c "6714".
- Belimumab casNumber "356547".
- Belimumab chemspiderid "NA".
- Belimumab h "10428".
- Belimumab hasPhotoCollection Belimumab.
- Belimumab kegg "D03068".
- Belimumab legalUs "Rx-only".
- Belimumab licenceUs "Benlysta".
- Belimumab mabType "mab".
- Belimumab medlineplus "a611027".
- Belimumab molecularWeight "151.8".
- Belimumab o "2102".
- Belimumab pregnancyUs "C".
- Belimumab routesOfAdministration Intravenous_therapy.
- Belimumab s "52".
- Belimumab source "u".
- Belimumab target B-cell_activating_factor.
- Belimumab tradename "Benlysta".
- Belimumab type "mab".
- Belimumab unii "73".
- Belimumab verifiedfields "changed".
- Belimumab verifiedrevid "458612180".
- Belimumab subject Category:Immunosuppressants.
- Belimumab subject Category:Monoclonal_antibodies.
- Belimumab type Abstraction100002137.
- Belimumab type Antibody115027189.
- Belimumab type Chemical114806838.
- Belimumab type Compound114818238.
- Belimumab type Macromolecule114944888.
- Belimumab type Material114580897.
- Belimumab type Matter100020827.
- Belimumab type Molecule114682133.
- Belimumab type MonoclonalAntibodies.
- Belimumab type MonoclonalAntibody115029781.
- Belimumab type OrganicCompound114727670.
- Belimumab type Part113809207.
- Belimumab type PhysicalEntity100001930.
- Belimumab type Protein114728724.
- Belimumab type Relation100031921.
- Belimumab type Substance100019613.
- Belimumab type Thing100002452.
- Belimumab type Unit109465459.
- Belimumab type Drug.
- Belimumab type DrugProduct.
- Belimumab type FunctionalSubstance.
- Belimumab comment "Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). B cells are responsible for part of the normal immune response, and also for the over-aggressive immune response in autoimmune diseases like systemic lupus erythematosus (SLE).Belimumab is approved in the United States, Canada and Europe for treatment of SLE.".
- Belimumab label "Belimumab".
- Belimumab label "Belimumab".
- Belimumab label "Belimumab".
- Belimumab label "Belimumab".
- Belimumab label "Belimumab".
- Belimumab label "بيليموماب".
- Belimumab sameAs Belimumab.
- Belimumab sameAs Belimumab.
- Belimumab sameAs Belimumab.
- Belimumab sameAs Belimumab.
- Belimumab sameAs m.027yjt9.
- Belimumab sameAs Q1996249.
- Belimumab sameAs Q1996249.
- Belimumab sameAs Belimumab.
- Belimumab wasDerivedFrom Belimumab?oldid=603979007.
- Belimumab isPrimaryTopicOf Belimumab.