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- Benzodiazepine_overdose abstract "Benzodiazepine overdose describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. Death as a result of taking an excessive dose of benzodiazepines alone is uncommon (vs Combined drug intoxication) but does occasionally happen. Deaths after hospital admission are considered to be low. However, combinations of high doses of benzodiazepines with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and may lead to severe complications such as coma or death. The most common symptoms of overdose include central nervous system (CNS) depression and intoxication with impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, Flumazenil (Romazicon), but its use is controversial.As benzodiazepines are one of the most highly prescribed classes of drugs they are commonly used in self-poisoning by drug overdose. The various benzodiazepines differ in their toxicity since they produce varying levels of sedation in overdose. A 1993 British study of deaths during the 1980s found flurazepam and temazepam more frequently involved in drug-related deaths causing more deaths per million prescriptions than other benzodiazepines. Flurazepam, now rarely prescribed in the United Kingdom and Australia, had the highest fatal toxicity index of any benzodiazepine (15.0), followed by temazepam (11.9), vs. benzodiazepines overall (5.9), taken with or without alcohol. An Australian (1995) study found oxazepam being less toxic and less sedative and temazepam more toxic and more sedative than most benzodiazepines in overdose. An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in the U.S. by a large margin, to be more toxic than diazepam and other benzodiazepines. They also cited a review of the Annual Reports of the American Association of Poison Control Centers National Data Collection System, which showed alprazolam was involved in 34 fatal deliberate self poisonings over 10 years 1992–2001, compared with 30 fatal deliberate self poisonings involving diazepam. In a New Zealand study (2003) of 200 deaths Zopiclone, a benzodiazepine receptor agonist had similar overdose potential as benzodiazepines.".
- Benzodiazepine_overdose emedicineSubject "article".
- Benzodiazepine_overdose emedicineTopic "813255".
- Benzodiazepine_overdose icd10 "F13.0, T42.4".
- Benzodiazepine_overdose icd9 "969.4".
- Benzodiazepine_overdose wikiPageID "20911040".
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- Benzodiazepine_overdose emedicinesubj "article".
- Benzodiazepine_overdose emedicinetopic "813255".
- Benzodiazepine_overdose hasPhotoCollection Benzodiazepine_overdose.
- Benzodiazepine_overdose icd "969.4".
- Benzodiazepine_overdose icd "F13.0, T42.4".
- Benzodiazepine_overdose name "Benzodiazepine overdose".
- Benzodiazepine_overdose subject Category:Benzodiazepines.
- Benzodiazepine_overdose subject Category:Poisoning_by_drugs,_medicaments_and_biological_substances.
- Benzodiazepine_overdose type Abstraction100002137.
- Benzodiazepine_overdose type Attribute100024264.
- Benzodiazepine_overdose type Condition113920835.
- Benzodiazepine_overdose type Disease114070360.
- Benzodiazepine_overdose type IllHealth114052046.
- Benzodiazepine_overdose type Illness114061805.
- Benzodiazepine_overdose type PathologicalState114051917.
- Benzodiazepine_overdose type PhysicalCondition114034177.
- Benzodiazepine_overdose type State100024720.
- Benzodiazepine_overdose type Disease.
- Benzodiazepine_overdose type AilmentCondition.
- Benzodiazepine_overdose type Situation.
- Benzodiazepine_overdose comment "Benzodiazepine overdose describes the ingestion of one of the drugs in the benzodiazepine class in quantities greater than are recommended or generally practiced. Death as a result of taking an excessive dose of benzodiazepines alone is uncommon (vs Combined drug intoxication) but does occasionally happen. Deaths after hospital admission are considered to be low.".
- Benzodiazepine_overdose label "Benzodiazepine overdose".
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- Benzodiazepine_overdose sameAs Q4890788.
- Benzodiazepine_overdose sameAs Q4890788.
- Benzodiazepine_overdose sameAs Benzodiazepine_overdose.
- Benzodiazepine_overdose wasDerivedFrom Benzodiazepine_overdose?oldid=606706609.
- Benzodiazepine_overdose isPrimaryTopicOf Benzodiazepine_overdose.
- Benzodiazepine_overdose name "Benzodiazepine overdose".