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- Beta-Hydroxy_beta-methylbutyric_acid abstract "Beta-Hydroxy beta-methylbutyric acid β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β-methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. Its part in protein synthesis was discovered by Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as the calcium salt calcium beta-hydroxy-beta-methylbutyrate.Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research.The same study lists as HMB's proposed mechanisms of action the following: Increased sarcolemmal integrity via conversion to HMG-CoA Enhanced protein synthesis via the mTOR pathway Depression of protein degradation through inhibition of the ubiquitin pathwayThe human body produces about 0.2-0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses. Toxicity at these doses is unlikely, as the no-observed-adverse-event-level (NOAEL) in rats is between 2.48 to 2.83 g/kg BW per day, roughly equivalent to 70 to 100 g/day in humans.".
- Beta-Hydroxy_beta-methylbutyric_acid iupacName "3-hydroxy-3-methylbutanoic acid".
- Beta-Hydroxy_beta-methylbutyric_acid thumbnail Hydroxymethylbutyric_acid.png?width=300.
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageID "2570928".
- Beta-Hydroxy_beta-methylbutyric_acid wikiPageRevisionID "599789252".
- Beta-Hydroxy_beta-methylbutyric_acid abbreviations "HMB".
- Beta-Hydroxy_beta-methylbutyric_acid hasPhotoCollection Beta-Hydroxy_beta-methylbutyric_acid.
- Beta-Hydroxy_beta-methylbutyric_acid imagefile "Hydroxymethylbutyric acid.png".
- Beta-Hydroxy_beta-methylbutyric_acid imagesize "150".
- Beta-Hydroxy_beta-methylbutyric_acid iupacname "3".
- Beta-Hydroxy_beta-methylbutyric_acid name "β-Hydroxy β-methylbutyric acid".
- Beta-Hydroxy_beta-methylbutyric_acid othernames "3".
- Beta-Hydroxy_beta-methylbutyric_acid othernames "β-Hydroxyisovaleric acid".
- Beta-Hydroxy_beta-methylbutyric_acid verifiedfields "changed".
- Beta-Hydroxy_beta-methylbutyric_acid verifiedrevid "444517582".
- Beta-Hydroxy_beta-methylbutyric_acid subject Category:Bodybuilding_supplements.
- Beta-Hydroxy_beta-methylbutyric_acid subject Category:Dietary_supplements.
- Beta-Hydroxy_beta-methylbutyric_acid subject Category:Hydroxy_acids.
- Beta-Hydroxy_beta-methylbutyric_acid type Abstraction100002137.
- Beta-Hydroxy_beta-methylbutyric_acid type Acid114607521.
- Beta-Hydroxy_beta-methylbutyric_acid type Addendum106399631.
- Beta-Hydroxy_beta-methylbutyric_acid type BodybuildingSupplements.
- Beta-Hydroxy_beta-methylbutyric_acid type Chemical114806838.
- Beta-Hydroxy_beta-methylbutyric_acid type Communication100033020.
- Beta-Hydroxy_beta-methylbutyric_acid type Compound114818238.
- Beta-Hydroxy_beta-methylbutyric_acid type HydroxyAcid114613922.
- Beta-Hydroxy_beta-methylbutyric_acid type HydroxyAcids.
- Beta-Hydroxy_beta-methylbutyric_acid type Material114580897.
- Beta-Hydroxy_beta-methylbutyric_acid type Matter100020827.
- Beta-Hydroxy_beta-methylbutyric_acid type Matter106365467.
- Beta-Hydroxy_beta-methylbutyric_acid type Part113809207.
- Beta-Hydroxy_beta-methylbutyric_acid type PhysicalEntity100001930.
- Beta-Hydroxy_beta-methylbutyric_acid type Relation100031921.
- Beta-Hydroxy_beta-methylbutyric_acid type Substance100019613.
- Beta-Hydroxy_beta-methylbutyric_acid type Writing106362953.
- Beta-Hydroxy_beta-methylbutyric_acid type WrittenCommunication106349220.
- Beta-Hydroxy_beta-methylbutyric_acid type ChemicalCompound.
- Beta-Hydroxy_beta-methylbutyric_acid type ChemicalSubstance.
- Beta-Hydroxy_beta-methylbutyric_acid type ChemicalSubstanceType.
- Beta-Hydroxy_beta-methylbutyric_acid type ChemicalObject.
- Beta-Hydroxy_beta-methylbutyric_acid type Thing.
- Beta-Hydroxy_beta-methylbutyric_acid comment "Beta-Hydroxy beta-methylbutyric acid β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β-methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. Its part in protein synthesis was discovered by Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement.".
- Beta-Hydroxy_beta-methylbutyric_acid label "3-Hydroxy-3-methylbuttersäure".
- Beta-Hydroxy_beta-methylbutyric_acid label "3-hydroxy-3-methylbutaanzuur".
- Beta-Hydroxy_beta-methylbutyric_acid label "3-ヒドロキシイソ吉草酸".
- Beta-Hydroxy_beta-methylbutyric_acid label "Acido 3-idrossi-3-metil-butirrico".
- Beta-Hydroxy_beta-methylbutyric_acid label "Beta-Hydroxy beta-methylbutyric acid".
- Beta-Hydroxy_beta-methylbutyric_acid label "Kwas 3-hydroksy-3-metylomasłowy".
- Beta-Hydroxy_beta-methylbutyric_acid label "Ácido beta-hidroxi-beta-metilbutírico".
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Hydroxymetylbutyrát.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs 3-Hydroxy-3-methylbuttersäure.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Acido_3-idrossi-3-metil-butirrico.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs 3-ヒドロキシイソ吉草酸.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs 3-hydroxy-3-methylbutaanzuur.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Kwas_3-hydroksy-3-metylomasłowy.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Ácido_beta-hidroxi-beta-metilbutírico.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs m.07ns6d.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Q223081.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Q223081.
- Beta-Hydroxy_beta-methylbutyric_acid sameAs Beta-Hydroxy_beta-methylbutyric_acid.
- Beta-Hydroxy_beta-methylbutyric_acid wasDerivedFrom Beta-Hydroxy_beta-methylbutyric_acid?oldid=599789252.
- Beta-Hydroxy_beta-methylbutyric_acid depiction Hydroxymethylbutyric_acid.png.
- Beta-Hydroxy_beta-methylbutyric_acid isPrimaryTopicOf Beta-Hydroxy_beta-methylbutyric_acid.
- Beta-Hydroxy_beta-methylbutyric_acid name "β-Hydroxy β-methylbutyric acid".