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- Beta-synuclein abstract "Beta-synuclein is a protein that in humans is encoded by the SNCB gene.The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.Beta-synuclein is a synuclein protein found primarily in brain tissue and is seen mainly in presynaptic terminals. Beta-synuclein is predominantly expressed in the neocortex, hippocampus, striatum, thalamus, and cerebellum. It is not found in Lewy bodies, but it is associated with hippocampal pathology in PD and DLB.Beta-synuclein is suggested to be an inhibitor of alpha-synuclein aggregation, which occurs in neurodegenerative diseases such as Parkinson's disease. Thus, beta-synuclein may protect the central nervous system from the neurotoxic effects of alpha-synuclein and provide a novel treatment of neurodegenerative disorders.".
- Beta-synuclein entrezgene "6620".
- Beta-synuclein wikiPageID "12651489".
- Beta-synuclein wikiPageRevisionID "590760515".
- Beta-synuclein hasPhotoCollection Beta-synuclein.
- Beta-synuclein requireManualInspection "no".
- Beta-synuclein summaryText "The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.".
- Beta-synuclein updateCitations "yes".
- Beta-synuclein updatePage "yes".
- Beta-synuclein updateProteinBox "yes".
- Beta-synuclein updateSummary "yes".
- Beta-synuclein type Biomolecule.
- Beta-synuclein type Protein.
- Beta-synuclein type BiologicalObject.
- Beta-synuclein comment "Beta-synuclein is a protein that in humans is encoded by the SNCB gene.The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease.".
- Beta-synuclein label "Beta-synuclein".
- Beta-synuclein sameAs m.02wzq9w.
- Beta-synuclein sameAs Q4897230.
- Beta-synuclein sameAs Q4897230.
- Beta-synuclein wasDerivedFrom Beta-synuclein?oldid=590760515.
- Beta-synuclein isPrimaryTopicOf Beta-synuclein.