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- Beta_thalassemia abstract "Beta thalassemias (β thalassemias) are a group of inherited blood disorders caused by reduced or absent synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world.Individuals with beta thalassemia major usually present within the first two years of life with severe anemia, poor growth, and skeletal abnormalities during infancy. Affected children will require regular lifelong blood transfusions. Beta thalassemia intermedia is less severe than beta thalassemia major and may require episodic blood transfusions. Transfusion-dependent patients will develop iron overload and require chelation therapy to remove the excess iron. Bone marrow transplants can be curative for some children with beta thalassemia major. Transmission is primarily autosomal recessive; however, dominant mutations have also been reported. Genetic counseling is recommended and prenatal diagnosis may be offered.The beta form of thalassemia is particularly prevalent among Mediterranean people and this geographical association is responsible for its naming: Thalassa (θάλασσα) is the Greek word for sea and Haema (αἷμα) is the Greek word for blood. In Europe, the highest concentrations of the disease are found in Greece,[citation needed] coastal regions in Turkey[citation needed] (particularly the Aegean Region such as Izmir, Balikesir, Aydin, Mugla, and Mediterranean Region such as Antalya, Adana, Mersin), in parts of Italy, particularly Southern Italy[citation needed] and the lower Po valley.[citation needed] The major Mediterranean islands (except the Balearics) such as Sicily, Sardinia, Malta, Corsica, Cyprus (18%), and Crete are heavily affected in particular. Other Mediterranean people, as well as those in the vicinity of the Mediterranean, also have high rates of thalassemia, including people from West Asia and North Africa. Far from the Mediterranean, South Asians are also affected,[citation needed] with the region's highest concentration of carriers (16% of the population) being in the Maldives.[citation needed]The thalassemia trait may confer a degree of protection against malaria, which is or was prevalent in the regions where the trait is common, thus conferring a selective survival advantage on carriers (known as heterozygous advantage), thus perpetuating the mutation. In that respect, the various thalassemias resemble another genetic disorder affecting hemoglobin, sickle-cell disease.".
- Beta_thalassemia diseasesdb "3087".
- Beta_thalassemia emedicineSubject "article".
- Beta_thalassemia emedicineTopic "199534".
- Beta_thalassemia icd10 "D56.1".
- Beta_thalassemia icd9 "282.44".
- Beta_thalassemia meshId "D017086".
- Beta_thalassemia omim "141900".
- Beta_thalassemia wikiPageExternalLink sickle-cell-thalassaemia-centre.
- Beta_thalassemia wikiPageExternalLink www.ferriscan.com.
- Beta_thalassemia wikiPageExternalLink 10001221.
- Beta_thalassemia wikiPageExternalLink NBK1426.
- Beta_thalassemia wikiPageExternalLink NBK1435.
- Beta_thalassemia wikiPageExternalLink 141800,141850,142310,604131,141800,141850,142310,604131.
- Beta_thalassemia wikiPageExternalLink www.nebata.co.uk.
- Beta_thalassemia wikiPageExternalLink www.thalassemia.com.
- Beta_thalassemia wikiPageExternalLink www.thalassemia.org.
- Beta_thalassemia wikiPageExternalLink www.thalassemia.us.
- Beta_thalassemia wikiPageExternalLink www.thalforum.com.
- Beta_thalassemia wikiPageExternalLink www.thalpal.com.
- Beta_thalassemia wikiPageID "5309210".
- Beta_thalassemia wikiPageRevisionID "600800464".
- Beta_thalassemia diseasesdb "3087".
- Beta_thalassemia emedicinesubj "article".
- Beta_thalassemia emedicinetopic "199534".
- Beta_thalassemia icd "282.44".
- Beta_thalassemia icd "D56.1".
- Beta_thalassemia meshid "D017086".
- Beta_thalassemia name "Beta thalassemia".
- Beta_thalassemia omim "141900".
- Beta_thalassemia subject Category:Disorders_of_globin_and_globulin_proteins.
- Beta_thalassemia subject Category:Hereditary_hemolytic_anemias.
- Beta_thalassemia type Disease.
- Beta_thalassemia type Situation.
- Beta_thalassemia comment "Beta thalassemias (β thalassemias) are a group of inherited blood disorders caused by reduced or absent synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals.".
- Beta_thalassemia label "Anemia mediterranea".
- Beta_thalassemia label "Beta thalassemia".
- Beta_thalassemia label "Beta-talasemia".
- Beta_thalassemia sameAs Beta-talasemia.
- Beta_thalassemia sameAs Anemia_mediterranea.
- Beta_thalassemia sameAs m.05fc6vp.
- Beta_thalassemia sameAs Q3616632.
- Beta_thalassemia sameAs Q3616632.
- Beta_thalassemia wasDerivedFrom Beta_thalassemia?oldid=600800464.
- Beta_thalassemia isPrimaryTopicOf Beta_thalassemia.
- Beta_thalassemia name "Beta thalassemia".