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- Bicarbonate_transporter_protein abstract "In molecular biology, bicarbonate transporter proteins are proteins which transport bicarbonate. Bicarbonate (HCO3 -) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO3 - transport modes. Anion exchanger proteins exchange HCO3 - for Cl- in a reversible, electroneutral manner. Na+/HCO3 - co-transport proteins mediate the coupled movement of Na+ and HCO3 - across plasma membranes, often in an electrogenic manner. Na- driven Cl-/HCO3 - exchange and K+/HCO3 - exchange activities have also been detected in certain cell types, although the molecular identities of the proteins responsible remain to be determined.Sequence analysis of the two families of HCO3 - transporters that have been cloned to date (the anion exchangers and Na+/HCO3 - co-transporters) reveals that they are homologous. This is not entirely unexpected, given that they both transport HCO3 - and are inhibited by a class of pharmacological agents called disulphonic stilbenes. They share around ~25-30% sequence identity, which is distributed along their entire sequence length, and have similar predicted membrane topologies, suggesting they have ~10 transmembrane (TM) domains.A conserved domain is found at the C terminus of many bicarbonate transport proteins. It is also found in some plant proteins responsible for boron transport. In these proteins it covers almost the entire length of the sequence.The Band 3 anion exchange proteins that exchange bicarbonate are the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of this domain are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).".
- Bicarbonate_transporter_protein symbol "Band_3_cyto".
- Bicarbonate_transporter_protein symbol "HCO3_cotransp".
- Bicarbonate_transporter_protein thumbnail PDB_1bh7_EBI.jpg?width=300.
- Bicarbonate_transporter_protein wikiPageID "32159238".
- Bicarbonate_transporter_protein wikiPageRevisionID "590763620".
- Bicarbonate_transporter_protein caption "a low energy structure for the final cytoplasmic loop of band 3, nmr, minimized average structure".
- Bicarbonate_transporter_protein caption "crystal structure of the cytoplasmic domain of human erythrocyte band-3 protein".
- Bicarbonate_transporter_protein hasPhotoCollection Bicarbonate_transporter_protein.
- Bicarbonate_transporter_protein interpro "IPR011531".
- Bicarbonate_transporter_protein interpro "IPR013769".
- Bicarbonate_transporter_protein name "Band 3 cytoplasmic domain".
- Bicarbonate_transporter_protein name "HCO3- transporter family".
- Bicarbonate_transporter_protein opmFamily "336".
- Bicarbonate_transporter_protein opmProtein "1".
- Bicarbonate_transporter_protein pfam "PF00955".
- Bicarbonate_transporter_protein pfam "PF07565".
- Bicarbonate_transporter_protein pfamClan "CL0062".
- Bicarbonate_transporter_protein pfamClan "CL0340".
- Bicarbonate_transporter_protein prosite "PDOC00192".
- Bicarbonate_transporter_protein scop "1".
- Bicarbonate_transporter_protein symbol "Band_3_cyto".
- Bicarbonate_transporter_protein symbol "HCO3_cotransp".
- Bicarbonate_transporter_protein tcdb "2".
- Bicarbonate_transporter_protein subject Category:Protein_families.
- Bicarbonate_transporter_protein subject Category:Transmembrane_transporters.
- Bicarbonate_transporter_protein type Abstraction100002137.
- Bicarbonate_transporter_protein type Family108078020.
- Bicarbonate_transporter_protein type Group100031264.
- Bicarbonate_transporter_protein type Organization108008335.
- Bicarbonate_transporter_protein type ProteinFamilies.
- Bicarbonate_transporter_protein type SocialGroup107950920.
- Bicarbonate_transporter_protein type Unit108189659.
- Bicarbonate_transporter_protein type YagoLegalActor.
- Bicarbonate_transporter_protein type YagoLegalActorGeo.
- Bicarbonate_transporter_protein type YagoPermanentlyLocatedEntity.
- Bicarbonate_transporter_protein type Biomolecule.
- Bicarbonate_transporter_protein type Protein.
- Bicarbonate_transporter_protein type BiologicalObject.
- Bicarbonate_transporter_protein comment "In molecular biology, bicarbonate transporter proteins are proteins which transport bicarbonate. Bicarbonate (HCO3 -) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO3 - transport modes.".
- Bicarbonate_transporter_protein label "Bicarbonate transporter protein".
- Bicarbonate_transporter_protein sameAs m.0gwyqhp.
- Bicarbonate_transporter_protein sameAs Q4903536.
- Bicarbonate_transporter_protein sameAs Q4903536.
- Bicarbonate_transporter_protein sameAs Bicarbonate_transporter_protein.
- Bicarbonate_transporter_protein wasDerivedFrom Bicarbonate_transporter_protein?oldid=590763620.
- Bicarbonate_transporter_protein depiction PDB_1bh7_EBI.jpg.
- Bicarbonate_transporter_protein isPrimaryTopicOf Bicarbonate_transporter_protein.