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- Bicifadine abstract "Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) developed by DOV Pharmaceutical. It has been developed as an analgesic and is currently under development for the treatment of various pain conditions. Phase III trials were completed in 2006 for treating chronic low back pain, and the drug is currently being tested to assess its efficacy in treating pain associated with osteoarthritis, acute post-surgical pain, neuropathic pain and pain associated with dental surgery.[1] Its usefulness in surgical or dental pain is dubious, however, as most monoamine uptake-inhibiting antidepressants have little if any effect in treating acute pain—they are only effective in cases of chronic neuropathic pain (much like their antidepressant properties, the analgesic properties of monoamine uptake inhibitors are not fully manifested until 1–2 weeks of continuous treatment).According to the ethymics website, Dov ran into difficulties in 2006 after bicifadine, a norepinephrine and serotonin reuptake inhibitor, failed in Phase III for chronic lower back pain (see BioCentury, July 26, 2010).Bicifadine represents a novel class of drug using a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad-spectrum monoamine transporter inhibitor or "triple reuptake inhibitor." While its efficacy at the DAT is lower than its efficacy at either the SERT or the NET, it is still capable of increasing the perisynaptic concentration of all three monoamines. Bicifadine is not the first antidepressant drug used in the treatment of pain, as the older tricyclic antidepressants (e.g. desipramine and amitriptyline) and the newer SNRI drug duloxetine have previously been approved for the treatment of neuropathic pain and disorders like fibromyalgia. Moreover, some weak or atypical opioid drugs such as tramadol and the newer agent tapentadol also function as noradrenaline reuptake inhibitors, a property that contributes to their overall therapeutic effect.Preliminary results suggest that bicifadine has an analgesic efficacy slightly stronger than codeine and approximately equivalent to tramadol, although side effects such as nausea and headache were more common with bicifadine than with tramadol.[2]".
- Bicifadine atcPrefix "none".
- Bicifadine casNumber "71195-57-8".
- Bicifadine fdaUniiCode "B0SV3N7J3H".
- Bicifadine iupacName "1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane".
- Bicifadine pubchem "47953".
- Bicifadine thumbnail Bicifadine_.svg?width=300.
- Bicifadine wikiPageExternalLink EUTHYMICS_BIOSCIENCE_ECP_BERNSTEIN_REPORT_120511bc1.pdf.
- Bicifadine wikiPageExternalLink products_body.html.
- Bicifadine wikiPageExternalLink index.php?option=com_content&task=view&id=48&Itemid=58.
- Bicifadine wikiPageID "14724536".
- Bicifadine wikiPageRevisionID "577144869".
- Bicifadine atcPrefix "none".
- Bicifadine c "12".
- Bicifadine casNumber "71195".
- Bicifadine chemspiderid "9889978".
- Bicifadine eliminationHalfLife "5760.0".
- Bicifadine excretion "renal".
- Bicifadine h "15".
- Bicifadine hasPhotoCollection Bicifadine.
- Bicifadine inchi "1".
- Bicifadine inchikey "OFYVIGTWSQPCLF-NWDGAFQWBL".
- Bicifadine iupacName "1".
- Bicifadine legalUs "Unscheduled".
- Bicifadine molecularWeight "173.25".
- Bicifadine n "1".
- Bicifadine pubchem "47953".
- Bicifadine routesOfAdministration "oral".
- Bicifadine smiles "c1cc[C@]32CNC[C@@H]2C3".
- Bicifadine stdinchi "1".
- Bicifadine stdinchikey "OFYVIGTWSQPCLF-NWDGAFQWSA-N".
- Bicifadine unii "B0SV3N7J3H".
- Bicifadine verifiedrevid "462798006".
- Bicifadine width "160".
- Bicifadine subject Category:Analgesics.
- Bicifadine subject Category:Cyclopropanes.
- Bicifadine subject Category:Pyrrolidines.
- Bicifadine subject Category:Serotonin-norepinephrine_reuptake_inhibitors.
- Bicifadine subject Category:Total_synthesis.
- Bicifadine type Agent114778436.
- Bicifadine type Analgesic102707683.
- Bicifadine type Analgesics.
- Bicifadine type Anesthetic102710766.
- Bicifadine type CausalAgent100007347.
- Bicifadine type Cyclopropane103155661.
- Bicifadine type Cyclopropanes.
- Bicifadine type Drug103247620.
- Bicifadine type GeneralAnesthetic103433434.
- Bicifadine type InhalationAnesthetic103570838.
- Bicifadine type Inhibitor114724436.
- Bicifadine type Matter100020827.
- Bicifadine type Medicine103740161.
- Bicifadine type PhysicalEntity100001930.
- Bicifadine type Serotonin-norepinephrineReuptakeInhibitors.
- Bicifadine type Substance100020090.
- Bicifadine type Drug.
- Bicifadine type DrugProduct.
- Bicifadine type FunctionalSubstance.
- Bicifadine comment "Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) developed by DOV Pharmaceutical. It has been developed as an analgesic and is currently under development for the treatment of various pain conditions.".
- Bicifadine label "Bicifadine".
- Bicifadine sameAs m.03gvmsh.
- Bicifadine sameAs Q4903628.
- Bicifadine sameAs Q4903628.
- Bicifadine sameAs Bicifadine.
- Bicifadine wasDerivedFrom Bicifadine?oldid=577144869.
- Bicifadine depiction Bicifadine_.svg.
- Bicifadine isPrimaryTopicOf Bicifadine.