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- Bifeprunox abstract "Bifeprunox (DU-127,090) is a novel atypical antipsychotic agent which, along with SLV313, aripiprazole, and SSR-181507 combines minimal D2 receptor agonism with 5-HT receptor agonism.Bifeprunox has a novel mechanism of action. Conventional antipsychotics are classed into typical and atypical. The typical antipsychotics, such as chlorpromazine and haloperidol are potent D2 receptor antagonists. The atypical antipsychotics started with clozapine, these are classified as multireceptor interacting compounds, acting as an agonist towards 5-HT1A and an antagonist towards D2 receptors among other 5-HT and DA receptors. Bifeprunox and other novel atypical antipsychotics will instead of antagonizing D2 receptors, will act as partial agonists, as well as partial agonists towards 5-HT1A receptors.In a multi-center, placebo-controlled study, 20 mg of bifeprunox was found to be significantly more effective than placebo at reducing symptoms of schizophrenia, with a low incidence of side effects.An NDA for Bifeprunox was filed with the U.S. Food and Drug Administration in January 2007. The FDA rejected the application in August 2007. In June 2009, Solvay and Lundbeck decided to cease development because "efficacy data did not support pursuing the existing development strategy of stabilisation of non-acute patients with schizophrenia."".
- Bifeprunox atcPrefix "none".
- Bifeprunox casNumber "350992-10-8".
- Bifeprunox fdaUniiCode "AP69E83Z79".
- Bifeprunox iupacName "7-[4-(biphenyl-3-ylmethyl)piperazin-1-yl]-1,3-benzoxazol-2(3H)-one".
- Bifeprunox pubchem "208951".
- Bifeprunox thumbnail Bifeprunox.png?width=300.
- Bifeprunox wikiPageID "11881741".
- Bifeprunox wikiPageRevisionID "590764116".
- Bifeprunox atcPrefix "none".
- Bifeprunox c "24".
- Bifeprunox casNumber "350992".
- Bifeprunox chembl "218166".
- Bifeprunox chemspiderid "181044".
- Bifeprunox h "23".
- Bifeprunox hasPhotoCollection Bifeprunox.
- Bifeprunox inchi "1".
- Bifeprunox inchikey "CYGODHVAJQTCBG-UHFFFAOYAL".
- Bifeprunox iupacName "7".
- Bifeprunox molecularWeight "385.458".
- Bifeprunox n "3".
- Bifeprunox o "2".
- Bifeprunox pubchem "208951".
- Bifeprunox smiles "O=C2Oc1cN5CCNCC5".
- Bifeprunox stdinchi "1".
- Bifeprunox stdinchikey "CYGODHVAJQTCBG-UHFFFAOYSA-N".
- Bifeprunox unii "AP69E83Z79".
- Bifeprunox verifiedfields "changed".
- Bifeprunox verifiedrevid "459978705".
- Bifeprunox subject Category:Atypical_antipsychotics.
- Bifeprunox subject Category:Benzoxazoles.
- Bifeprunox subject Category:Carbamates.
- Bifeprunox subject Category:Piperazines.
- Bifeprunox type Agent114778436.
- Bifeprunox type AtypicalAntipsychotics.
- Bifeprunox type CausalAgent100007347.
- Bifeprunox type Drug103247620.
- Bifeprunox type DrugOfAbuse103248958.
- Bifeprunox type MajorTranquilizer103713736.
- Bifeprunox type Matter100020827.
- Bifeprunox type Medicine103740161.
- Bifeprunox type PhysicalEntity100001930.
- Bifeprunox type Piperazine103946814.
- Bifeprunox type Piperazines.
- Bifeprunox type PsychotropicAgent104017429.
- Bifeprunox type Sedative-hypnotic104166841.
- Bifeprunox type Sedative104166553.
- Bifeprunox type Substance100020090.
- Bifeprunox type Tranquilizer104470232.
- Bifeprunox type Vermifuge104528630.
- Bifeprunox type Drug.
- Bifeprunox type DrugProduct.
- Bifeprunox type FunctionalSubstance.
- Bifeprunox comment "Bifeprunox (DU-127,090) is a novel atypical antipsychotic agent which, along with SLV313, aripiprazole, and SSR-181507 combines minimal D2 receptor agonism with 5-HT receptor agonism.Bifeprunox has a novel mechanism of action. Conventional antipsychotics are classed into typical and atypical. The typical antipsychotics, such as chlorpromazine and haloperidol are potent D2 receptor antagonists.".
- Bifeprunox label "Bifeprunox".
- Bifeprunox sameAs m.02rwmqh.
- Bifeprunox sameAs Q4904729.
- Bifeprunox sameAs Q4904729.
- Bifeprunox sameAs Bifeprunox.
- Bifeprunox wasDerivedFrom Bifeprunox?oldid=590764116.
- Bifeprunox depiction Bifeprunox.png.
- Bifeprunox isPrimaryTopicOf Bifeprunox.