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- Brasofensine abstract "Brasofensine (NS-2214, BMS-204756) is a phenyltropane that had been under development for the treatment of Parkinson's and Alzheimer's disease. Phase II trials were conducted in 1996 and brasofensine was shown to be both effective and well tolerated at a dose of 4 mg, however development was stopped after in vivo cis-anti isomerization of the 2α-methyloxime group was reported. In animal models of Parkinson's disease, brasofensine was effective in stimulating LMA and reversing akinesia.The isomerization of brasofensine is not between the alpha and beta positions on the 2 position of the tropane ring but rather the E/Z isomerization of the imine (i.e. "methyl-aldoxime"). It was believed that this process occurs in vivo although it cannot be ruled out as a possibility that some isomerization also occurs prior to ingestion.The (Z)-isomer has been consigned the name BMS-205912In PD, symptoms do not begin to manifest until there has been an 80% reduction in dopaminergic neurons, particularly in the substantia nigra brain region.".
- Brasofensine atcPrefix "none".
- Brasofensine casNumber "171655-91-7".
- Brasofensine fdaUniiCode "1YP2S94RVH".
- Brasofensine iupacName "(+)-(E)-1-[(1R,2R,3S)-3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carbaldehyde O-methyloxime".
- Brasofensine pubchem "9614919".
- Brasofensine thumbnail Brasofensine.svg?width=300.
- Brasofensine wikiPageExternalLink cocaineanalogs.pdf.
- Brasofensine wikiPageID "12862491".
- Brasofensine wikiPageRevisionID "604999315".
- Brasofensine atcPrefix "none".
- Brasofensine c "16".
- Brasofensine casNumber "171655".
- Brasofensine chemspiderid "7888898".
- Brasofensine cl "2".
- Brasofensine h "20".
- Brasofensine hasPhotoCollection Brasofensine.
- Brasofensine inchi "1".
- Brasofensine inchikey "NRLIFEGHTNUYFL-QJDHNRDABN".
- Brasofensine iupacName "--1-[-3--8-methyl-8-azabicyclo[3.2.1]octane-2-carbaldehyde O-methyloxime".
- Brasofensine legalUk "Class A".
- Brasofensine molecularWeight "327.249".
- Brasofensine n "2".
- Brasofensine o "1".
- Brasofensine pubchem "9614919".
- Brasofensine smiles "Clc1ccc[C@H]3C[C@H]2N[C@H][C@@H]3\C=N\OC".
- Brasofensine stdinchi "1".
- Brasofensine stdinchikey "NRLIFEGHTNUYFL-QJDHNRDASA-N".
- Brasofensine unii "1".
- Brasofensine verifiedrevid "437723330".
- Brasofensine subject Category:Oximes.
- Brasofensine subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- Brasofensine subject Category:Stimulants.
- Brasofensine subject Category:Sympathomimetic_amines.
- Brasofensine subject Category:Tropanes.
- Brasofensine type Abstraction100002137.
- Brasofensine type AliphaticCompound114601294.
- Brasofensine type Amine114739004.
- Brasofensine type Chemical114806838.
- Brasofensine type Cognition100023271.
- Brasofensine type Compound114818238.
- Brasofensine type Information105816287.
- Brasofensine type Material114580897.
- Brasofensine type Matter100020827.
- Brasofensine type MethaneSeries114951377.
- Brasofensine type OrganicCompound114727670.
- Brasofensine type Oxime114972092.
- Brasofensine type Oximes.
- Brasofensine type Part113809207.
- Brasofensine type PhysicalEntity100001930.
- Brasofensine type PsychologicalFeature100023100.
- Brasofensine type Relation100031921.
- Brasofensine type Stimulants.
- Brasofensine type Stimulation105827684.
- Brasofensine type Substance100019613.
- Brasofensine type SympathomimeticAmines.
- Brasofensine type Drug.
- Brasofensine type DrugProduct.
- Brasofensine type FunctionalSubstance.
- Brasofensine comment "Brasofensine (NS-2214, BMS-204756) is a phenyltropane that had been under development for the treatment of Parkinson's and Alzheimer's disease. Phase II trials were conducted in 1996 and brasofensine was shown to be both effective and well tolerated at a dose of 4 mg, however development was stopped after in vivo cis-anti isomerization of the 2α-methyloxime group was reported.".
- Brasofensine label "Brasofensine".
- Brasofensine sameAs m.02x8ch8.
- Brasofensine sameAs Q4957842.
- Brasofensine sameAs Q4957842.
- Brasofensine sameAs Brasofensine.
- Brasofensine wasDerivedFrom Brasofensine?oldid=604999315.
- Brasofensine depiction Brasofensine.svg.
- Brasofensine isPrimaryTopicOf Brasofensine.