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- Bretazenil abstract "Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988. It is most closely related in structure to the benzodiazepine antagonist flumazenil, although its effects are somewhat different. It is classed as a high-potency benzodiazepine due to its high affinity binding to benzodiazepine binding sites where it acts as a partial agonist. Its profile as a partial agonist and preclinical trial data suggests that it may have a reduced adverse effect profile. In particular bretazenil has been proposed to cause a less strong development of tolerance and withdrawal syndrome. Bretazenil differs from traditional 1,4 benzodiazepines by being a partial agonist and because it binds to alpha,1, 2, 3, 4, 5 and 6 subunit containing GABAA benzodiazepine receptor complexes. 1,4 benzodiazepines bind only to alpha 1, 2, 3 and 5 GABAA benzodiazepine receptor complexes.".
- Bretazenil atcPrefix "none".
- Bretazenil casNumber "84379-13-5".
- Bretazenil fdaUniiCode "OSZ0E9DGOJ".
- Bretazenil iupacName "t-butyl-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo(1,5-a)-pyrrolo(2,1-c)(1,4)benzodiazepine-1-carboxylate".
- Bretazenil pubchem "107926".
- Bretazenil thumbnail Bretazenil_.svg?width=300.
- Bretazenil wikiPageID "4716245".
- Bretazenil wikiPageRevisionID "593854457".
- Bretazenil atcPrefix "none".
- Bretazenil br "1".
- Bretazenil c "19".
- Bretazenil casNumber "84379".
- Bretazenil chembl "366947".
- Bretazenil chemspiderid "97049".
- Bretazenil eliminationHalfLife "9000.0".
- Bretazenil h "20".
- Bretazenil hasPhotoCollection Bretazenil.
- Bretazenil image "Bretazenil ball-and-stick animation.gif".
- Bretazenil inchi "1".
- Bretazenil inchikey "LWUDDYHYYNNIQI-ZDUSSCGKBA".
- Bretazenil iupacName "t-butyl-8-bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo-pyrrolobenzodiazepine-1-carboxylate".
- Bretazenil molecularWeight "418.284".
- Bretazenil n "3".
- Bretazenil o "3".
- Bretazenil pubchem "107926".
- Bretazenil smiles "O=Cc1ncn2c4ccccc4".
- Bretazenil stdinchi "1".
- Bretazenil stdinchikey "LWUDDYHYYNNIQI-ZDUSSCGKSA-N".
- Bretazenil unii "OSZ0E9DGOJ".
- Bretazenil verifiedrevid "437191831".
- Bretazenil width "180".
- Bretazenil subject Category:Carboxylate_esters.
- Bretazenil subject Category:Imidazopyrrolobenzodiazepines.
- Bretazenil subject Category:Lactams.
- Bretazenil subject Category:Organobromides.
- Bretazenil type Abstraction100002137.
- Bretazenil type CarboxylateEsters.
- Bretazenil type Chemical114806838.
- Bretazenil type Compound114818238.
- Bretazenil type Ester114850483.
- Bretazenil type Material114580897.
- Bretazenil type Matter100020827.
- Bretazenil type OrganicCompound114727670.
- Bretazenil type Part113809207.
- Bretazenil type PhysicalEntity100001930.
- Bretazenil type Relation100031921.
- Bretazenil type Substance100019613.
- Bretazenil type Drug.
- Bretazenil type DrugProduct.
- Bretazenil type FunctionalSubstance.
- Bretazenil comment "Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988. It is most closely related in structure to the benzodiazepine antagonist flumazenil, although its effects are somewhat different. It is classed as a high-potency benzodiazepine due to its high affinity binding to benzodiazepine binding sites where it acts as a partial agonist.".
- Bretazenil label "Bretazenil".
- Bretazenil label "Bretazenil".
- Bretazenil sameAs Bretazenil.
- Bretazenil sameAs m.0cjt88.
- Bretazenil sameAs Q4961977.
- Bretazenil sameAs Q4961977.
- Bretazenil sameAs Bretazenil.
- Bretazenil wasDerivedFrom Bretazenil?oldid=593854457.
- Bretazenil depiction Bretazenil_.svg.
- Bretazenil isPrimaryTopicOf Bretazenil.