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- Buchwald–Hartwig_amination abstract "The Buchwald–Hartwig amination is a chemical reaction used in organic chemistry for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed cross-coupling of amines with aryl halides. Though publications with similar focus were published as early as 1983, credit for its development is typically assigned to Stephen L. Buchwald and John F. Hartwig, whose publications between 1994 and the late 2000s established the scope of the transformation. The reaction's synthetic utility stems primarily from the shortcomings of typical methods (nucleophilic substitution, reductive amination, etc.) for the synthesis of aromatic C–N bonds, with most methods suffering from limited substrate scope and functional group tolerance. The development of the Buchwald–Hartwig reaction allowed for the facile synthesis of aryl amines, replacing to an extent harsher methods (the Goldberg reaction, nucleophilic aromatic substitution, etc.) while significantly expanding the repertoire of possible C–N bond formation.Over the course of its development, several 'generations' of catalyst systems have been developed, with each system allowing greater scope in terms of coupling partners and milder conditions, allowing virtually any amine to be coupled with a wide variety of aryl coupling partners. Because of the ubiquity of aryl C-N bonds in pharmaceuticals and natural products, the reaction has gained wide use in synthetic organic chemistry, finding application in many total syntheses and the industrial preparation of numerous pharmaceuticals. Several reviews have been published.".
- Buchwald–Hartwig_amination thumbnail Buchwaldhartwig.png?width=300.
- Buchwald–Hartwig_amination wikiPageID "6691097".
- Buchwald–Hartwig_amination wikiPageRevisionID "585063324".
- Buchwald–Hartwig_amination subject Category:Name_reactions.
- Buchwald–Hartwig_amination subject Category:Substitution_reactions.
- Buchwald–Hartwig_amination comment "The Buchwald–Hartwig amination is a chemical reaction used in organic chemistry for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed cross-coupling of amines with aryl halides. Though publications with similar focus were published as early as 1983, credit for its development is typically assigned to Stephen L. Buchwald and John F. Hartwig, whose publications between 1994 and the late 2000s established the scope of the transformation.".
- Buchwald–Hartwig_amination label "Aminación de Buchwald-Hartwig".
- Buchwald–Hartwig_amination label "Buchwald-Hartwig-Kupplung".
- Buchwald–Hartwig_amination label "Buchwald-Hartwig-aminering".
- Buchwald–Hartwig_amination label "Buchwald–Hartwig amination".
- Buchwald–Hartwig_amination label "Buchwald–Hartwig偶联反应".
- Buchwald–Hartwig_amination label "Reazione di Buchwald-Hartwig".
- Buchwald–Hartwig_amination label "Réaction de Buchwald-Hartwig".
- Buchwald–Hartwig_amination label "ブッフバルト・ハートウィッグ反応".
- Buchwald–Hartwig_amination sameAs Buchwald%E2%80%93Hartwig_amination.
- Buchwald–Hartwig_amination sameAs Buchwald-Hartwig-Kupplung.
- Buchwald–Hartwig_amination sameAs Aminación_de_Buchwald-Hartwig.
- Buchwald–Hartwig_amination sameAs Réaction_de_Buchwald-Hartwig.
- Buchwald–Hartwig_amination sameAs Reazione_di_Buchwald-Hartwig.
- Buchwald–Hartwig_amination sameAs ブッフバルト・ハートウィッグ反応.
- Buchwald–Hartwig_amination sameAs Buchwald-Hartwig-aminering.
- Buchwald–Hartwig_amination sameAs Q904693.
- Buchwald–Hartwig_amination sameAs Q904693.
- Buchwald–Hartwig_amination wasDerivedFrom Buchwald–Hartwig_amination?oldid=585063324.
- Buchwald–Hartwig_amination depiction Buchwaldhartwig.png.