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- Butriptyline abstract "Butriptyline (Evadene, Evadyne, Evasidol, Centrolese) is a tricyclic antidepressant (TCA) which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline and produces similar effects to it, but with less marked side effects like sedation and interactions with adrenergic drugs.In vitro, butriptyline is a strong antihistamine and anticholinergic, moderate 5-HT2 and α1-adrenergic receptor antagonist, and weak serotonin reuptake inhibitor, with negligible affinity for the norepinephrine and dopamine transporters. These actions appear to confer a profile similar to that of iprindole and trimipramine with serotonin-blocking effects as the predominant mediator of mood-lifting efficacy.However, in clinical trials, using similar doses, butriptyline was found to be even more effective than amitriptyline as an antidepressant, despite the fact that amitriptyline is much, much stronger as both a 5-HT2 antagonist and serotonin-norepinephrine reuptake inhibitor. As a result, it can be inferred that butriptyline, in vivo, may function as a prodrug to a metabolite with more appreciable pharmacodynamics.".
- Butriptyline atcPrefix "N06".
- Butriptyline atcSuffix "AA15".
- Butriptyline casNumber "35941-65-2".
- Butriptyline fdaUniiCode "Z22441975X".
- Butriptyline iupacName "(±)-3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-yl)-N,N,2-trimethylpropan-1-amine".
- Butriptyline pubchem "21772".
- Butriptyline thumbnail Butriptyline.svg?width=300.
- Butriptyline wikiPageID "5900878".
- Butriptyline wikiPageRevisionID "590839483".
- Butriptyline atcPrefix "N06".
- Butriptyline atcSuffix "AA15".
- Butriptyline c "21".
- Butriptyline casNumber "35941".
- Butriptyline chemspiderid "20462".
- Butriptyline drugName "Butriptyline".
- Butriptyline eliminationHalfLife "72000.0".
- Butriptyline h "27".
- Butriptyline hasPhotoCollection Butriptyline.
- Butriptyline imagename "1".
- Butriptyline inchi "1".
- Butriptyline inchikey "ALELTFCQZDXAMQ-UHFFFAOYAG".
- Butriptyline iupacName "-3".
- Butriptyline kegg "D07601".
- Butriptyline legalStatus "Rx-only".
- Butriptyline molecularWeight "293.446".
- Butriptyline n "1".
- Butriptyline pubchem "21772".
- Butriptyline routesOfAdministration "Oral".
- Butriptyline smiles "c1cc3cCCc2cC3CCCNC".
- Butriptyline stdinchi "1".
- Butriptyline stdinchikey "ALELTFCQZDXAMQ-UHFFFAOYSA-N".
- Butriptyline unii "Z22441975X".
- Butriptyline verifiedrevid "447573132".
- Butriptyline subject Category:Dibenzocycloheptenes.
- Butriptyline subject Category:Tricyclic_antidepressants.
- Butriptyline type Agent114778436.
- Butriptyline type Antidepressant102718811.
- Butriptyline type CausalAgent100007347.
- Butriptyline type Drug103247620.
- Butriptyline type Matter100020827.
- Butriptyline type Medicine103740161.
- Butriptyline type PhysicalEntity100001930.
- Butriptyline type Substance100020090.
- Butriptyline type Tricyclic104482543.
- Butriptyline type TricyclicAntidepressants.
- Butriptyline type Drug.
- Butriptyline type DrugProduct.
- Butriptyline type FunctionalSubstance.
- Butriptyline comment "Butriptyline (Evadene, Evadyne, Evasidol, Centrolese) is a tricyclic antidepressant (TCA) which has been used in Europe since 1974.".
- Butriptyline label "Butriptilina".
- Butriptyline label "Butriptylin".
- Butriptyline label "Butriptyline".
- Butriptyline sameAs Butriptylin.
- Butriptyline sameAs Butriptilina.
- Butriptyline sameAs m.0fcn56.
- Butriptyline sameAs Q904524.
- Butriptyline sameAs Q904524.
- Butriptyline sameAs Butriptyline.
- Butriptyline wasDerivedFrom Butriptyline?oldid=590839483.
- Butriptyline depiction Butriptyline.svg.
- Butriptyline isPrimaryTopicOf Butriptyline.
- Butriptyline name "Butriptyline".