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- C1_domain abstract "C1 domain (also known as phorbol esters/diacylglycerol binding domain) binds an important secondary messenger diacylglycerol (DAG), as well as the analogous phorbol esters. Phorbol esters can directly stimulate protein kinase C, PKC. The N-terminal region of PKC, known as C1, has been shownPhorbol esters (such as PMA) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC). Phorbol esters can directly stimulate PKC. The N-terminal region of PKC, known as C1, binds PMA and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PMA-binding. The DAG/PMA-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.".
- C1_domain symbol "C1".
- C1_domain thumbnail 1ptr.png?width=300.
- C1_domain wikiPageID "8394993".
- C1_domain wikiPageRevisionID "588630680".
- C1_domain caption "C1 domain of PKC-delta Middle plane of the lipid bilayer - black dots. Boundary of the hydrocarbon core region - blue dots . Layer of lipid phosphates - yellow dots.".
- C1_domain hasPhotoCollection C1_domain.
- C1_domain interpro "IPR002219".
- C1_domain name "Phorbol esters/diacylglycerol binding domain".
- C1_domain opmFamily "63".
- C1_domain opmProtein "1".
- C1_domain pdb ":231-280 :231-280 A:215-267 A:567-616 :139-187 :139-187 A:334-378 A:334-378 A:236-286".
- C1_domain pfam "PF00130".
- C1_domain prosite "PDOC00379".
- C1_domain scop "2".
- C1_domain smart "1.0".
- C1_domain symbol "1.0".
- C1_domain width "200".
- C1_domain subject Category:Peripheral_membrane_proteins.
- C1_domain subject Category:Protein_domains.
- C1_domain type Biomolecule.
- C1_domain type Protein.
- C1_domain type BiologicalObject.
- C1_domain comment "C1 domain (also known as phorbol esters/diacylglycerol binding domain) binds an important secondary messenger diacylglycerol (DAG), as well as the analogous phorbol esters. Phorbol esters can directly stimulate protein kinase C, PKC. The N-terminal region of PKC, known as C1, has been shownPhorbol esters (such as PMA) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues.".
- C1_domain label "C1 domain".
- C1_domain label "C1ドメイン".
- C1_domain label "Dominio C1".
- C1_domain sameAs Dominio_C1.
- C1_domain sameAs C1ドメイン.
- C1_domain sameAs m.0271yt7.
- C1_domain sameAs Q3277956.
- C1_domain sameAs Q3277956.
- C1_domain wasDerivedFrom C1_domain?oldid=588630680.
- C1_domain depiction 1ptr.png.
- C1_domain isPrimaryTopicOf C1_domain.