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- CAP_protein_family abstract "In molecular biology, the CAP protein family (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)) is a large family of proteins that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes. The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The calcium-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate.Many of these proteins contain a Crisp domain. This domain is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor calcium signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.".
- CAP_protein_family symbol "CAP".
- CAP_protein_family symbol "Crisp".
- CAP_protein_family thumbnail PDB_1smb_EBI.jpg?width=300.
- CAP_protein_family wikiPageID "32189100".
- CAP_protein_family wikiPageRevisionID "590854518".
- CAP_protein_family caption "crystal structure of golgi-associated pr-1 protein".
- CAP_protein_family caption "crystal structure of stecrisp, a member of crisp family from trimeresurus stejnegeri refined at 1.6 angstroms resolution: structural relationship of the two domains".
- CAP_protein_family hasPhotoCollection CAP_protein_family.
- CAP_protein_family interpro "IPR013871".
- CAP_protein_family interpro "IPR014044".
- CAP_protein_family name "CAP".
- CAP_protein_family name "Crisp domain".
- CAP_protein_family pfam "PF00188".
- CAP_protein_family pfam "PF08562".
- CAP_protein_family pfamClan "CL0213".
- CAP_protein_family prosite "PDOC00835".
- CAP_protein_family scop "1".
- CAP_protein_family symbol "CAP".
- CAP_protein_family symbol "Crisp".
- CAP_protein_family subject Category:Protein_domains.
- CAP_protein_family type Abstraction100002137.
- CAP_protein_family type Attribute100024264.
- CAP_protein_family type Environment113934596.
- CAP_protein_family type ProteinDomains.
- CAP_protein_family type Situation113927383.
- CAP_protein_family type Sphere114514039.
- CAP_protein_family type State100024720.
- CAP_protein_family type Biomolecule.
- CAP_protein_family type Protein.
- CAP_protein_family type BiologicalObject.
- CAP_protein_family comment "In molecular biology, the CAP protein family (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)) is a large family of proteins that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes.".
- CAP_protein_family label "CAP protein family".
- CAP_protein_family sameAs m.0gy1f5f.
- CAP_protein_family sameAs Q5008779.
- CAP_protein_family sameAs Q5008779.
- CAP_protein_family sameAs CAP_protein_family.
- CAP_protein_family wasDerivedFrom CAP_protein_family?oldid=590854518.
- CAP_protein_family depiction PDB_1smb_EBI.jpg.
- CAP_protein_family isPrimaryTopicOf CAP_protein_family.