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- CSE_protein_family abstract "In molecular biology, the CAS/CSE protein family is a family of proteins which includes mammalian cellular apoptosis susceptibility (CAS) proteins and yeast chromosome-segregation protein, CSE1. CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation. Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle, as is the protein MEK, which is thought to regulate the intracellular localization (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins.The CAS/CSE family of proteins consist of two domains. An N-terminal Cse1 domain, which contains HEAT repeats, and a C-terminal domain.".
- CSE_protein_family symbol "CAS_CSE1".
- CSE_protein_family symbol "Cse1".
- CSE_protein_family thumbnail PDB_1z3h_EBI.jpg?width=300.
- CSE_protein_family wikiPageID "32190659".
- CSE_protein_family wikiPageRevisionID "590863913".
- CSE_protein_family caption "the exportin cse1 in its cargo-free, cytoplasmic state".
- CSE_protein_family hasPhotoCollection CSE_protein_family.
- CSE_protein_family interpro "IPR005043".
- CSE_protein_family interpro "IPR013713".
- CSE_protein_family name "CAS/CSE protein, C-terminus".
- CSE_protein_family name "Cse1".
- CSE_protein_family pfam "PF03378".
- CSE_protein_family pfam "PF08506".
- CSE_protein_family pfamClan "CL0020".
- CSE_protein_family symbol "CAS_CSE1".
- CSE_protein_family symbol "Cse1".
- CSE_protein_family subject Category:Protein_families.
- CSE_protein_family type Abstraction100002137.
- CSE_protein_family type Family108078020.
- CSE_protein_family type Group100031264.
- CSE_protein_family type Organization108008335.
- CSE_protein_family type ProteinFamilies.
- CSE_protein_family type SocialGroup107950920.
- CSE_protein_family type Unit108189659.
- CSE_protein_family type YagoLegalActor.
- CSE_protein_family type YagoLegalActorGeo.
- CSE_protein_family type YagoPermanentlyLocatedEntity.
- CSE_protein_family type Biomolecule.
- CSE_protein_family type Protein.
- CSE_protein_family type BiologicalObject.
- CSE_protein_family comment "In molecular biology, the CAS/CSE protein family is a family of proteins which includes mammalian cellular apoptosis susceptibility (CAS) proteins and yeast chromosome-segregation protein, CSE1. CAS is involved in both cellular apoptosis and proliferation. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation.".
- CSE_protein_family label "CAS/CSE protein family".
- CSE_protein_family sameAs m.0gxzry4.
- CSE_protein_family sameAs Q5008842.
- CSE_protein_family sameAs Q5008842.
- CSE_protein_family sameAs CSE_protein_family.
- CSE_protein_family wasDerivedFrom CSE_protein_family?oldid=590863913.
- CSE_protein_family depiction PDB_1z3h_EBI.jpg.
- CSE_protein_family isPrimaryTopicOf CSE_protein_family.