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- CCK-4 abstract "Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2; also PTK7) is a peptide fragment derived from the larger peptide hormone cholecystokinin. Unlike cholecystokin which has a variety of roles in the gastrointenstinal system as well as central nervous system effects, CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58. CCK-4 reliably causes severe anxiety symptoms when administered to humans in a dose of as little as 50μg,and is commonly used in scientific research to induce panic attacks for the purpose of testing new anxiolytic drugs.Since it is a peptide, CCK-4 must be administered by injection, and is rapidly broken down once inside the body so has only a short duration of action, although numerous synthetic analogues with modified properties are known.".
- CCK-4 bioavailability "100.0".
- CCK-4 casNumber "1947-37-1".
- CCK-4 iupacName "(3S)-3-[(2S)-2-amino-3-phenylpropanamido]-3-{[(1S)-1-{[(1S)-1-carboxy -2-(indol-3-yl)ethyl]carbamoyl}-3-(methylsulfanyl)propyl]carbamoyl}propanoic acid".
- CCK-4 thumbnail CCK-4.png?width=300.
- CCK-4 wikiPageID "17849155".
- CCK-4 wikiPageRevisionID "590872709".
- CCK-4 bioavailability "100.0".
- CCK-4 c "29".
- CCK-4 casNumber "1947".
- CCK-4 chemspiderid "27470965".
- CCK-4 eliminationHalfLife "780.0".
- CCK-4 excretion "N/A".
- CCK-4 h "35".
- CCK-4 hasPhotoCollection CCK-4.
- CCK-4 inchi "1".
- CCK-4 inchikey "LQHGVXZMXPZBOC-BIHRQFPBBX".
- CCK-4 iupacName "-3".
- CCK-4 metabolism "plasma protease enzymes".
- CCK-4 molecularWeight "597.681".
- CCK-4 n "5".
- CCK-4 o "7".
- CCK-4 routesOfAdministration "IV".
- CCK-4 s "1".
- CCK-4 smiles "c3cccc1c3ncc1CCNCCNCCNCCCc2ccccc2".
- CCK-4 stdinchi "1".
- CCK-4 stdinchikey "LQHGVXZMXPZBOC-BIHRQFPBSA-N".
- CCK-4 verifiedfields "changed".
- CCK-4 verifiedrevid "431772029".
- CCK-4 watchedfields "changed".
- CCK-4 width "240".
- CCK-4 subject Category:Anxiogenics.
- CCK-4 subject Category:Cholecystokinin.
- CCK-4 subject Category:Peptides.
- CCK-4 subject Category:Thioethers.
- CCK-4 type Drug.
- CCK-4 type DrugProduct.
- CCK-4 type FunctionalSubstance.
- CCK-4 comment "Cholecystokinin tetrapeptide (CCK-4, Trp-Met-Asp-Phe-NH2; also PTK7) is a peptide fragment derived from the larger peptide hormone cholecystokinin. Unlike cholecystokin which has a variety of roles in the gastrointenstinal system as well as central nervous system effects, CCK-4 acts primarily in the brain as an anxiogenic, although it does retain some GI effects, but not as much as CCK-8 or the full length polypeptide CCK-58.".
- CCK-4 label "CCK-4".
- CCK-4 label "Тетрапептид холецистокинина".
- CCK-4 sameAs m.0478vvj.
- CCK-4 sameAs Q4456650.
- CCK-4 sameAs Q4456650.
- CCK-4 wasDerivedFrom CCK-4?oldid=590872709.
- CCK-4 depiction CCK-4.png.
- CCK-4 isPrimaryTopicOf CCK-4.