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- COX-inhibiting_nitric_oxide_donator abstract "COX-inhibiting nitric oxide donators (CINODs), also known as NO-NSAIDs, are a new class of non-steroidal anti-inflammatory drug (NSAID) developed with the intention of providing greater safety than existing NSAIDs.These compounds were first described by John Wallace and colleagues. CINODs are compounds generated by the fusion of an existing NSAID with a nitric oxide (NO)-donating moiety by chemical means, usually by ester linkage. CINODs retain the anti-inflammatory efficacy of NSAIDs via inhibition of cyclooxygenase (COX) while arguably improving upon gastric and vascular safety, most likely via vasorelaxation, inhibition of leukocyte adhesion and inhibition of caspases, all known effects of NO. The first CINODs were developed in the 1990s, and as yet none have been approved for use by the general public. The importance of developing such drugs was increased when COX-2-specific NSAIDs rofecoxib (Vioxx) and lumiracoxib (Prexige) were removed from major pharmaceutical markets in the mid-2000s due to vascular safety concerns. In addition, traditional NSAIDs increase blood pressure and interfere with the actions of antihypertensive drugs. Several CINODs are currently being tested in clinical trials, the most advanced of which are being conducted by the French pharmaceutical company NicOx, whose flagship compound naproxcinod (NO-naproxen, nitronaproxen) is in phase III trials for the treatment of osteoarthritis. Naproxcinod is a fusion of naproxen and a NO-donating group. Other CINODs are also being tested by NicOx for the treatment of diseases in which inflammation plays a role.".
- COX-inhibiting_nitric_oxide_donator wikiPageID "14911980".
- COX-inhibiting_nitric_oxide_donator wikiPageRevisionID "600024054".
- COX-inhibiting_nitric_oxide_donator hasPhotoCollection COX-inhibiting_nitric_oxide_donator.
- COX-inhibiting_nitric_oxide_donator subject Category:Non-steroidal_anti-inflammatory_drugs.
- COX-inhibiting_nitric_oxide_donator type Agent114778436.
- COX-inhibiting_nitric_oxide_donator type Anti-inflammatory102721538.
- COX-inhibiting_nitric_oxide_donator type CausalAgent100007347.
- COX-inhibiting_nitric_oxide_donator type Drug103247620.
- COX-inhibiting_nitric_oxide_donator type Matter100020827.
- COX-inhibiting_nitric_oxide_donator type Medicine103740161.
- COX-inhibiting_nitric_oxide_donator type Non-steroidalAnti-inflammatoryDrugs.
- COX-inhibiting_nitric_oxide_donator type PhysicalEntity100001930.
- COX-inhibiting_nitric_oxide_donator type Substance100020090.
- COX-inhibiting_nitric_oxide_donator comment "COX-inhibiting nitric oxide donators (CINODs), also known as NO-NSAIDs, are a new class of non-steroidal anti-inflammatory drug (NSAID) developed with the intention of providing greater safety than existing NSAIDs.These compounds were first described by John Wallace and colleagues. CINODs are compounds generated by the fusion of an existing NSAID with a nitric oxide (NO)-donating moiety by chemical means, usually by ester linkage.".
- COX-inhibiting_nitric_oxide_donator label "COX-inhibiting nitric oxide donator".
- COX-inhibiting_nitric_oxide_donator label "COX-inhibiting nitric oxide donator".
- COX-inhibiting_nitric_oxide_donator label "COX-inibitori a rilascio di monossido di azoto".
- COX-inhibiting_nitric_oxide_donator sameAs COX-inhibiting_nitric_oxide_donator.
- COX-inhibiting_nitric_oxide_donator sameAs COX-inibitori_a_rilascio_di_monossido_di_azoto.
- COX-inhibiting_nitric_oxide_donator sameAs m.03h198m.
- COX-inhibiting_nitric_oxide_donator sameAs Q2931854.
- COX-inhibiting_nitric_oxide_donator sameAs Q2931854.
- COX-inhibiting_nitric_oxide_donator sameAs COX-inhibiting_nitric_oxide_donator.
- COX-inhibiting_nitric_oxide_donator wasDerivedFrom COX-inhibiting_nitric_oxide_donator?oldid=600024054.
- COX-inhibiting_nitric_oxide_donator isPrimaryTopicOf COX-inhibiting_nitric_oxide_donator.