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- CYP2D6 abstract "Cytochrome P450 2D6 is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. CYP2D6 a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. In particular, CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs. This enzyme also metabolizes several endogenous substances such as hydroxytryptamines and neurosteroids.There is considerable variation in the efficiency and amount of CYP2D6 enzyme produced between individuals. Hence for drugs that are metabolized by CYP2D6 (that is, are CYP2D6 substrates), certain individuals will eliminate these drugs quickly (ultrarapid metabolizers) while others slowly (poor metabolizers). If a drug is metabolized too quickly, it may decrease the drug's efficacy while if the drug is metabolized too slowly, toxicity may result. Hence the dose of the drug may have to be adjusted to take into account of the speed at which it is metabolized by CYP2D6.In addition, other drugs may function as inhibitors of CYP2D6 activity or inducers of CYP2D6 enzyme expression that will lead to decreased or increased CYP2D6 activity respectively. If such a drug is taken at the same time a second drug who is a CYP2D6 substrate, the first drug may affect the elimination rate of the second through what is known as a drug-drug interaction.".
- CYP2D6 entrezgene "1565".
- CYP2D6 wikiPageExternalLink 2D6sub.
- CYP2D6 wikiPageExternalLink index.jsp.
- CYP2D6 wikiPageID "1024815".
- CYP2D6 wikiPageRevisionID "605936198".
- CYP2D6 hasPhotoCollection CYP2D6.
- CYP2D6 subject Category:Amphetamine.
- CYP2D6 subject Category:Cytochrome_P450.
- CYP2D6 subject Category:EC_1.14.14.
- CYP2D6 type Biomolecule.
- CYP2D6 type Protein.
- CYP2D6 type BiologicalObject.
- CYP2D6 comment "Cytochrome P450 2D6 is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. CYP2D6 a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. In particular, CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs.".
- CYP2D6 label "CYP2D6".
- CYP2D6 label "CYP2D6".
- CYP2D6 label "CYP2D6".
- CYP2D6 label "CYP2D6".
- CYP2D6 label "Cytochrom P450 2D6".
- CYP2D6 label "سيتوكروم 2دي6".
- CYP2D6 sameAs Cytochrom_P450_2D6.
- CYP2D6 sameAs CYP2D6.
- CYP2D6 sameAs Sitokrom_P450_2D6.
- CYP2D6 sameAs CYP2D6.
- CYP2D6 sameAs CYP2D6.
- CYP2D6 sameAs CYP2D6.
- CYP2D6 sameAs m.03_983.
- CYP2D6 sameAs Q3271142.
- CYP2D6 sameAs Q3271142.
- CYP2D6 sameAs CYP2D6.
- CYP2D6 sameAs 32.
- CYP2D6 sameAs 4119.
- CYP2D6 sameAs 5718.
- CYP2D6 wasDerivedFrom CYP2D6?oldid=605936198.
- CYP2D6 isPrimaryTopicOf CYP2D6.