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- CYT387 abstract "CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM).As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions.The drug was originally discovered by Australian drug discovery company Cytopia, now it is developed by YM BioSciences Inc.".
- CYT387 iupacName "N-(Cyanomethyl)-4-[2-(4-morpholinoanilino)pyrimidin-4-yl]benzamide".
- CYT387 thumbnail CYT387.svg?width=300.
- CYT387 wikiPageExternalLink cyt387.php.
- CYT387 wikiPageID "33938099".
- CYT387 wikiPageRevisionID "546264873".
- CYT387 hasPhotoCollection CYT387.
- CYT387 imagefile "CYT387.svg".
- CYT387 imagesize "200".
- CYT387 iupacname "N--4-[2-pyrimidin-4-yl]benzamide".
- CYT387 othernames "CYT 11387".
- CYT387 subject Category:Benzamides.
- CYT387 subject Category:Morpholines.
- CYT387 subject Category:Nitriles.
- CYT387 subject Category:Non-receptor_tyrosine_kinase_inhibitors.
- CYT387 subject Category:Protein_kinase_inhibitors.
- CYT387 subject Category:Pyrimidines.
- CYT387 type ChemicalCompound.
- CYT387 type ChemicalSubstance.
- CYT387 type ChemicalObject.
- CYT387 type Thing.
- CYT387 comment "CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM).As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials.".
- CYT387 label "CYT387".
- CYT387 sameAs m.0hncmfv.
- CYT387 sameAs Q252602.
- CYT387 sameAs Q252602.
- CYT387 wasDerivedFrom CYT387?oldid=546264873.
- CYT387 depiction CYT387.svg.
- CYT387 isPrimaryTopicOf CYT387.