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- Cancer_genome_sequencing abstract "Cancer genome sequencing is the whole genome sequencing of a single, homogeneous or heterogeneous group of cancer cells. It is a biochemical laboratory method for the characterization and identification of the DNA or RNA sequences of cancer cell(s).Unlike whole genome (WG) sequencing which is typically from blood cells, such as J. Craig Venter's and James D. Watson’s WG sequencing projects, saliva, epithelial cells or bone - cancer genome sequencing involves direct sequencing of primary tumor tissue, adjacent or distal normal tissue, the tumor micro environment such as fibroblast/stromal cells, or metastatic tumor sites.Similar to whole genome sequencing, the information generated from this technique include: identification of nucleotide bases (DNA or RNA), copy number and sequence variants, mutation status, and structural changes such as chromosomal translocations and fusion genes.Cancer genome sequencing is not limited to WG sequencing and can also includes exome, transcriptome, and micronome sequencing. These methods can be used to quantify gene expression, miRNA expression, and identify alternative splicing events in addition to sequence data.The first report of cancer genome sequencing appeared in 2006 [3]. In this study 13,023 genes were sequenced in 11 breast and 11 colorectal tumors. A subsequent follow up was published in 2007 where the same group added just over 5,000 more genes and almost 8,000 transcript species to complete the exomes of 11 breast and colorectal tumors [4]. A cancer genome to be sequenced was from cytogenetically normal acute myeloid leukaemia by Ley et al. in November 2008. The first breast cancer tumor was sequenced by Shah et al. in October 2009, the first lung and skin tumors by Pleasance et al. in January 2010, and the first prostate tumors by Berger et al. in February 2011. All were published in Nature.".
- Cancer_genome_sequencing wikiPageExternalLink cancergenome.nih.gov.
- Cancer_genome_sequencing wikiPageExternalLink cgap.nci.nih.gov.
- Cancer_genome_sequencing wikiPageExternalLink CGAP.
- Cancer_genome_sequencing wikiPageExternalLink www.icgc.org.
- Cancer_genome_sequencing wikiPageExternalLink CGP.
- Cancer_genome_sequencing wikiPageExternalLink cancergenome.
- Cancer_genome_sequencing wikiPageExternalLink article.cfm?id=mapping-the-cancer-genome.
- Cancer_genome_sequencing wikiPageID "26062564".
- Cancer_genome_sequencing wikiPageRevisionID "597666710".
- Cancer_genome_sequencing hasPhotoCollection Cancer_genome_sequencing.
- Cancer_genome_sequencing subject Category:Genomics.
- Cancer_genome_sequencing comment "Cancer genome sequencing is the whole genome sequencing of a single, homogeneous or heterogeneous group of cancer cells. It is a biochemical laboratory method for the characterization and identification of the DNA or RNA sequences of cancer cell(s).Unlike whole genome (WG) sequencing which is typically from blood cells, such as J. Craig Venter's and James D.".
- Cancer_genome_sequencing label "Cancer genome sequencing".
- Cancer_genome_sequencing sameAs m.0b6nlhv.
- Cancer_genome_sequencing sameAs Q17082639.
- Cancer_genome_sequencing sameAs Q17082639.
- Cancer_genome_sequencing wasDerivedFrom Cancer_genome_sequencing?oldid=597666710.
- Cancer_genome_sequencing isPrimaryTopicOf Cancer_genome_sequencing.