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- Casomorphin abstract "Casomorphins are peptides, i.e., protein fragments, derived from the digestion of milk protein casein. The distinguishing characteristic of casomorphins is that they have an opioid effect.The most important casomorphins from bovine milk are those released from the digestion of β-casein into β-casomorphins, sometimes denoted as BCM followed by a numeral indicating the number of amino acids in the sequence. In cattle, the amount of β-casein - and, hence, the potential release of β-casomorphins - varies between species and breeds. Typically, β-casein comprises about one-third of the casein in milk, or about 12 grams per liter of milk. However, there are at least 13 different variants of the β-casein protein in cattle population, with any one cow producing milk that will contain either one or two of these 13 variants. β-casomorphins are found in cheeses made from bovine milk; their concentrations are higher in mould cheeses (e.g. Brie, Rokpol) than in semi-hard cheeses (e.g. Edam, Gouda and Kasztelan).Each variant fits into one of two main categories known as A1 and A2. In cattle, A1-type β-caseins have the amino acid histidine at position 67, whereas the A2-type β-caseins have the amino acid proline at position 67. Laboratory experiments show that the casomorphin known as BCM7 is released only from the A1-type β-caseins. The potential release of BCM7 is about 0.4 grams per litre of milk (assuming as above that there are 12g of β-casein per litre).Human digestion may break down casomorphins into inactive dipeptides by the enzyme dipeptidyl peptidase-4. This enzyme is found in the digestive tract and in some endocrine cells.There is also the potential for release of casomorphins from human milk. However, human BCM7 (Tyr-Pro-Phe-Val-Glu-Pro-Ile) differs from the bovine form (Tyr-Pro-Phe-Pro-Gly-Pro-Ile) at two amino acid positions.Scientific understanding of the biochemistry and pharmacology of casomorphins is incomplete. A recent scientific review is provided by Kaminski et al. (2007).".
- Casomorphin thumbnail Bovine_β-casomorphin_7.png?width=300.
- Casomorphin wikiPageExternalLink EFSA_datex_report_beta_casomorphins_en.pdf.
- Casomorphin wikiPageID "1058293".
- Casomorphin wikiPageRevisionID "603065530".
- Casomorphin hasPhotoCollection Casomorphin.
- Casomorphin subject Category:Opioid_peptides.
- Casomorphin type Abstraction100002137.
- Casomorphin type Amide114724264.
- Casomorphin type Chemical114806838.
- Casomorphin type Compound114818238.
- Casomorphin type Material114580897.
- Casomorphin type Matter100020827.
- Casomorphin type OrganicCompound114727670.
- Casomorphin type Part113809207.
- Casomorphin type Peptide114743046.
- Casomorphin type Peptides.
- Casomorphin type PhysicalEntity100001930.
- Casomorphin type Relation100031921.
- Casomorphin type Substance100019613.
- Casomorphin comment "Casomorphins are peptides, i.e., protein fragments, derived from the digestion of milk protein casein. The distinguishing characteristic of casomorphins is that they have an opioid effect.The most important casomorphins from bovine milk are those released from the digestion of β-casein into β-casomorphins, sometimes denoted as BCM followed by a numeral indicating the number of amino acids in the sequence.".
- Casomorphin label "Casomorfina".
- Casomorphin label "Casomorphin".
- Casomorphin label "Casomorphin".
- Casomorphin label "Casomorphine".
- Casomorphin label "Казоморфин".
- Casomorphin label "カソモルフィン".
- Casomorphin sameAs Casomorphin.
- Casomorphin sameAs Casomorphine.
- Casomorphin sameAs カソモルフィン.
- Casomorphin sameAs Casomorfina.
- Casomorphin sameAs m.042bvd.
- Casomorphin sameAs Q425309.
- Casomorphin sameAs Q425309.
- Casomorphin sameAs Casomorphin.
- Casomorphin wasDerivedFrom Casomorphin?oldid=603065530.
- Casomorphin depiction Bovine_β-casomorphin_7.png.
- Casomorphin isPrimaryTopicOf Casomorphin.