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- Cerulenin abstract "Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA. Inhibition involves covalent thioacylation that permanently inactivates the enzymes. These two behaviors may increase the availability of energy in the form of ATP, perhaps sensed by AMPK, in the hypothalamus.In sterol synthesis, cerulenin inhibits HMG-CoA synthetase activity. It was also reported that cerulenin specifically inhibited fatty acid biosynthesis in Saccharomyces cerevisiae without having an effect on sterol formation. But in general conclusion, cerulenin has inhibitory effects on sterol synthesis.Cerulenin causes a dose-dependent decrease in HER2/neu protein levels in breast cancer cells, from 14% at 1.25 to 78% at 10 milligrams per liter, and targeting of fatty acid synthase by related drugs has been suggested as a possible treatment. Antiproliferative and pro-apoptotic effects have been shown in colon cells as well. At an intraperitoneal dose of 30 milligrams per kilogram, it has been shown to inhibit feeding and induce dramatic weight loss in mice by a mechanism similar to, but independent or downstream of, leptin signaling. It is found naturally in the industrial strain Cephalosporium caerulens (Sarocladium oryzae, the sheath rot pathogen of rice).".
- Cerulenin iupacName "(2R,​3S)-​3-​[(4E,​7E)-​nona-​4,​7-​dienoyl]​oxirane-​2-​carboxamide".
- Cerulenin thumbnail Cerulenin.svg?width=300.
- Cerulenin wikiPageExternalLink cerulenin.htm.
- Cerulenin wikiPageID "4207339".
- Cerulenin wikiPageRevisionID "606355814".
- Cerulenin hasPhotoCollection Cerulenin.
- Cerulenin imagefile "Cerulenin.svg".
- Cerulenin imagesize "280".
- Cerulenin iupacname "-​3-​[-​nona-​4,​7-​dienoyl]​oxirane-​2-​carboxamide".
- Cerulenin verifiedfields "changed".
- Cerulenin verifiedrevid "401951338".
- Cerulenin watchedfields "changed".
- Cerulenin subject Category:Alkenes.
- Cerulenin subject Category:Amides.
- Cerulenin subject Category:Antifungals.
- Cerulenin subject Category:Epoxides.
- Cerulenin subject Category:Ketones.
- Cerulenin type Abstraction100002137.
- Cerulenin type AliphaticCompound114601294.
- Cerulenin type Alkene114713120.
- Cerulenin type Alkenes.
- Cerulenin type Amide114724264.
- Cerulenin type Amides.
- Cerulenin type Chemical114806838.
- Cerulenin type Compound114818238.
- Cerulenin type Ketone114926294.
- Cerulenin type Ketones.
- Cerulenin type Material114580897.
- Cerulenin type Matter100020827.
- Cerulenin type OrganicCompound114727670.
- Cerulenin type Part113809207.
- Cerulenin type PhysicalEntity100001930.
- Cerulenin type Relation100031921.
- Cerulenin type Substance100019613.
- Cerulenin type ChemicalCompound.
- Cerulenin type ChemicalSubstance.
- Cerulenin type ChemicalSubstanceType.
- Cerulenin type ChemicalObject.
- Cerulenin type Thing.
- Cerulenin comment "Cerulenin is an antifungal antibiotic that inhibits fatty acid and steroid biosynthesis. In fatty acid synthesis, it has been reported to bind in equimolar ratio to b-keto-acyl-ACP synthase, one of the seven moieties of fatty acid synthase, blocking the interaction of malonyl-CoA. It also has the related activity of stimulating fatty acid oxidation through the activation of CPT1, another enzyme normally inhibited by malonyl-CoA.".
- Cerulenin label "Cerulenin".
- Cerulenin sameAs m.0bp_r1.
- Cerulenin sameAs Q5065296.
- Cerulenin sameAs Q5065296.
- Cerulenin sameAs DB01034.
- Cerulenin sameAs Cerulenin.
- Cerulenin wasDerivedFrom Cerulenin?oldid=606355814.
- Cerulenin depiction Cerulenin.svg.
- Cerulenin isPrimaryTopicOf Cerulenin.