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- Chordin abstract "Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally identified in Xenopus laevis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. The polypeptide is 941 amino acids long and 120 kDa large and it dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.In mice, Chordin is expressed in the node but not in the anterior visceral endoderm. It has been found to be required for forebrain development. In developing mice that are deficient in both chordin and noggin, the head is nearly absent. This is significant because when only noggin is deficient there are mild defects but the head still forms.In humans, the chordin peptide is encoded by the CHRD gene.Chordin is also involved in avian gastrulation. It is expressed in the anterior cells of Koller's sickle, which form the anterior cells of the primitive streak, a key structure through which gastrulation occurs.".
- Chordin arm "q".
- Chordin band "27".
- Chordin chromosome "3".
- Chordin entrezgene "8646".
- Chordin hgncid "1949".
- Chordin omim "603475".
- Chordin refseq "NM_003741".
- Chordin symbol "CHRD".
- Chordin uniprot "Q9H2X0".
- Chordin wikiPageID "5737035".
- Chordin wikiPageRevisionID "593739708".
- Chordin arm "q".
- Chordin band "27".
- Chordin chromosome "3".
- Chordin entrezgene "8646".
- Chordin hasPhotoCollection Chordin.
- Chordin hgncid "1949".
- Chordin interpro "IPR010895".
- Chordin name "CHRD domain".
- Chordin name "chordin".
- Chordin omim "603475".
- Chordin pfam "PF07452".
- Chordin prosite "PS50933".
- Chordin refseq "NM_003741".
- Chordin smart "SM00754".
- Chordin symbol "CHRD".
- Chordin uniprot "Q9H2X0".
- Chordin subject Category:CHRD_domain.
- Chordin subject Category:Developmental_biology.
- Chordin subject Category:Proteins.
- Chordin subject Category:VWFC_domain.
- Chordin type Abstraction100002137.
- Chordin type Chemical114806838.
- Chordin type Compound114818238.
- Chordin type Macromolecule114944888.
- Chordin type Material114580897.
- Chordin type Matter100020827.
- Chordin type Molecule114682133.
- Chordin type OrganicCompound114727670.
- Chordin type Part113809207.
- Chordin type PhysicalEntity100001930.
- Chordin type Protein114728724.
- Chordin type Proteins.
- Chordin type Relation100031921.
- Chordin type Substance100019613.
- Chordin type Thing100002452.
- Chordin type Unit109465459.
- Chordin type Biomolecule.
- Chordin type Protein.
- Chordin type ProteinMolecule.
- Chordin type BiologicalObject.
- Chordin comment "Chordin is a bone morphogenetic protein antagonist composed of four small cysteine-rich domains, whose function is not known. Chordin was originally identified in Xenopus laevis as a key developmental protein that dorsalizes early vertebrate embryonic tissues. The polypeptide is 941 amino acids long and 120 kDa large and it dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins. It may also play a role in organogenesis.".
- Chordin label "Chordin".
- Chordin label "Chordine".
- Chordin sameAs Chordine.
- Chordin sameAs Chordyna.
- Chordin sameAs m.0f20vx.
- Chordin sameAs Q2964503.
- Chordin sameAs Q2964503.
- Chordin sameAs Chordin.
- Chordin wasDerivedFrom Chordin?oldid=593739708.
- Chordin isPrimaryTopicOf Chordin.