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- Chromatin_remodeling abstract "Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, i.e., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes. Besides actively regulating gene expression, dynamic remodeling of chromatin imparts an epigenetic regulatory role in several key biological processes, e.g., DNA replication and repair; apoptosis; chromosome segregation as well as development and pluripotency. Aberrations in chromatin remodeling proteins are found to be associated with human diseases, including cancer. Targeting chromatin remodeling pathways is currently evolving as a major therapeutic strategy in the treatment of several cancers.".
- Chromatin_remodeling thumbnail Sha-Boyer-Fig1-CCBy3.0.jpg?width=300.
- Chromatin_remodeling wikiPageExternalLink go-0000785.
- Chromatin_remodeling wikiPageExternalLink go-0006323.
- Chromatin_remodeling wikiPageExternalLink nrg3607.html.
- Chromatin_remodeling wikiPageExternalLink watch?v=Tj_6DcUTRnM&feature=related.
- Chromatin_remodeling wikiPageExternalLink watch?v=eYrQ0EhVCYA&feature=related.
- Chromatin_remodeling wikiPageID "12197312".
- Chromatin_remodeling wikiPageRevisionID "599948671".
- Chromatin_remodeling hasPhotoCollection Chromatin_remodeling.
- Chromatin_remodeling subject Category:Cancer.
- Chromatin_remodeling subject Category:Epigenetics.
- Chromatin_remodeling subject Category:Gene_expression.
- Chromatin_remodeling comment "Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the regulatory transcription machinery proteins, and thereby control gene expression. Such remodeling is principally carried out by 1) covalent histone modifications by specific enzymes, i.e., histone acetyltransferases (HATs), deacetylases, methyltransferases, and kinases, and 2) ATP-dependent chromatin remodeling complexes which either move, eject or restructure nucleosomes.".
- Chromatin_remodeling label "Chromatin remodeling".
- Chromatin_remodeling label "Ремоделирование хроматина".
- Chromatin_remodeling sameAs m.09v2pbj.
- Chromatin_remodeling sameAs Q5113739.
- Chromatin_remodeling sameAs Q5113739.
- Chromatin_remodeling wasDerivedFrom Chromatin_remodeling?oldid=599948671.
- Chromatin_remodeling depiction Sha-Boyer-Fig1-CCBy3.0.jpg.
- Chromatin_remodeling isPrimaryTopicOf Chromatin_remodeling.