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- Cilengitide abstract "Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology. Hence, it is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.The European Medicines Agency has granted cilengitide orphan drug status.Cilengitide seems to function by inhibiting the FAK/src/AKT pathway and inducing apoptosis in endothelial cells [4]. Preclinical studies in mice of cilengitide were able to demonstrate efficacious tumor regression.Phase II studies were able to demonstrate that cilengitide as a potential monotherapy in patients with recurrent glioblastoma with high intratumor drug levels when 2000 mg of cilengitide is given twice weekly. In a rat xenograft model, cilengitide was able to potentiate the cytotoxic effects of radiation when cilengitide was administered prior to radiation therapy. When combined with radiation, inhibition of integrin expression by cilengitide synergistically improves the cytotoxic effects of ionizing radiation for glioblastoma. Cilengitide is well tolerated, in combination with radiation and temozolomide, at a dose of 2000 mg in patients with newly diagnosed glioblastoma, regardless of MGMT promoter status. In a phase I/IIa study, the addition of cilengitide to the standard of care for newly diagnosed glioblastoma (surgical resection followed by temozolomide and radiation therapy) improves progression-free survival and overall survival in patients with MGMT promoter methylation.However, in a subsequent study, cilengitide does not seem to alter the pattern of glioblastoma progression, and in an EORTC phase III randomized, controlled, multicenter clinical trial, consisting of over 500 patients in 23 countries, the addition of cilengitide to the standard of care did not improve overall survival in patients with newly diagnosed glioblastoma and methylated MGMT promoter status A phase II study, the CORE trial, is currently being conducted in patients with newly diagnosed glioblastoma and unmethylated MGMT promoter status.".
- Cilengitide fdaUniiCode "4EDF46E4GI".
- Cilengitide iupacName "2-[(2S,5R,8S,11S)-5-benzyl-11-{3-[(diaminomethylidene)amino]propyl}-7-methyl-3,6,9,12,15-pentaoxo-8-(propan-2-yl)-1,4,7,10,13-pentaazacyclopentadecan-2-yl]acetic acid".
- Cilengitide thumbnail Cilengitide.svg?width=300.
- Cilengitide wikiPageID "10244438".
- Cilengitide wikiPageRevisionID "601317254".
- Cilengitide hasPhotoCollection Cilengitide.
- Cilengitide imagefile "Cilengitide.svg".
- Cilengitide imagesize "300".
- Cilengitide iupacname "2".
- Cilengitide unii "4".
- Cilengitide verifiedfields "changed".
- Cilengitide verifiedrevid "460036937".
- Cilengitide watchedfields "changed".
- Cilengitide subject Category:Experimental_cancer_drugs.
- Cilengitide subject Category:Macrocycles.
- Cilengitide subject Category:Orphan_drugs.
- Cilengitide subject Category:Peptides.
- Cilengitide type Agent114778436.
- Cilengitide type Antineoplastic102722458.
- Cilengitide type CausalAgent100007347.
- Cilengitide type CytotoxicDrug103157987.
- Cilengitide type Drug103247620.
- Cilengitide type ExperimentalCancerDrugs.
- Cilengitide type Matter100020827.
- Cilengitide type Medicine103740161.
- Cilengitide type OrphanDrugs.
- Cilengitide type PhysicalEntity100001930.
- Cilengitide type Substance100020090.
- Cilengitide type ChemicalCompound.
- Cilengitide type ChemicalSubstance.
- Cilengitide type ChemicalSubstanceType.
- Cilengitide type ChemicalObject.
- Cilengitide type Thing.
- Cilengitide comment "Cilengitide is a molecule designed and synthesized at the Technical University Munich in collaboration with Merck KGaA in Darmstadt. It is based on the cyclic peptide cyclo(-RGDfV-), which is selective for αv integrins, which are important in angiogenesis (forming new blood vessels), and other aspects of tumor biology.".
- Cilengitide label "Cilengitide".
- Cilengitide sameAs Cilengitid.
- Cilengitide sameAs m.02q6bst.
- Cilengitide sameAs Q1091921.
- Cilengitide sameAs Q1091921.
- Cilengitide sameAs Cilengitide.
- Cilengitide wasDerivedFrom Cilengitide?oldid=601317254.
- Cilengitide depiction Cilengitide.svg.
- Cilengitide isPrimaryTopicOf Cilengitide.