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- Citrate_synthase abstract "The enzyme citrate synthase (E.C. 2.3.3.1 [previously 4.1.3.7]) exists in nearly all living cells and stands as a pace-making enzyme in the first step of the Citric Acid Cycle (or Krebs Cycle). Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix. Citrate synthase is commonly used as a quantitative enzyme marker for the presence of intact mitochondria.Citrate synthase catalyzes the condensation reaction of the two-carbon acetate residue from acetyl coenzyme A and a molecule of four-carbon oxaloacetate to form the six-carbon citrate. Oxaloacetate will be regenerated after the completion of one round of the Krebs Cycle. acetyl-CoA + oxaloacetate + H2O → citrate + CoA-SHOxaloacetate is the first substrate to bind to the enzyme. This induces the enzyme to change its conformation, and creates a binding site for the acetyl-CoA. Only when this citroyl-CoA has formed will another conformational change cause thioester hydrolysis and release coenzyme A. This ensures that the energy released from the thioester bond cleavage will drive the condensation.".
- Citrate_synthase arm "p".
- Citrate_synthase band "11-qter".
- Citrate_synthase chromosome "12".
- Citrate_synthase ecNumber "2.3.3.1".
- Citrate_synthase entrezgene "1431".
- Citrate_synthase hgncid "2422".
- Citrate_synthase omim "118950".
- Citrate_synthase symbol "CS".
- Citrate_synthase thumbnail Citrate_Synthase_(open_form).png?width=300.
- Citrate_synthase uniprot "O75390".
- Citrate_synthase wikiPageID "3830525".
- Citrate_synthase wikiPageRevisionID "552970787".
- Citrate_synthase arm "p".
- Citrate_synthase band "11".
- Citrate_synthase chromosome "12".
- Citrate_synthase ecnumber "2.3".
- Citrate_synthase entrezgene "1431".
- Citrate_synthase hasPhotoCollection Citrate_synthase.
- Citrate_synthase hgncid "2422".
- Citrate_synthase name "Citrate synthase".
- Citrate_synthase omim "118950".
- Citrate_synthase symbol "CS".
- Citrate_synthase uniprot "O75390".
- Citrate_synthase subject Category:Cell_biology.
- Citrate_synthase subject Category:EC_2.3.3.
- Citrate_synthase type Biomolecule.
- Citrate_synthase type Protein.
- Citrate_synthase type ProteinMolecule.
- Citrate_synthase type BiologicalObject.
- Citrate_synthase comment "The enzyme citrate synthase (E.C. 2.3.3.1 [previously 4.1.3.7]) exists in nearly all living cells and stands as a pace-making enzyme in the first step of the Citric Acid Cycle (or Krebs Cycle). Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than mitochondrial. It is synthesized using cytoplasmic ribosomes, then transported into the mitochondrial matrix.".
- Citrate_synthase label "Citraatsynthase".
- Citrate_synthase label "Citrat-Synthase".
- Citrate_synthase label "Citrate synthase".
- Citrate_synthase label "Citrate synthase".
- Citrate_synthase label "Citrato (Si)-sintasi".
- Citrate_synthase label "Citrato sintase".
- Citrate_synthase label "Синтетаза цитрата".
- Citrate_synthase label "クエン酸シンターゼ".
- Citrate_synthase label "柠檬酸合酶".
- Citrate_synthase sameAs Citrátsyntáza.
- Citrate_synthase sameAs Citrat-Synthase.
- Citrate_synthase sameAs Citrate_synthase.
- Citrate_synthase sameAs Citrato_(Si)-sintasi.
- Citrate_synthase sameAs クエン酸シンターゼ.
- Citrate_synthase sameAs Citraatsynthase.
- Citrate_synthase sameAs Citrato_sintase.
- Citrate_synthase sameAs m.0b25yd.
- Citrate_synthase sameAs Q416426.
- Citrate_synthase sameAs Q416426.
- Citrate_synthase wasDerivedFrom Citrate_synthase?oldid=552970787.
- Citrate_synthase depiction Citrate_Synthase_(open_form).png.
- Citrate_synthase isPrimaryTopicOf Citrate_synthase.
- Citrate_synthase name "Citrate synthase".