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- Cixutumumab abstract "Cixutumumab is a monoclonal antibody for the treatment of solid tumors.This drug was developed by ImClone Systems Inc. under the name IMC-A12.It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.".
- Cixutumumab atcPrefix "none".
- Cixutumumab casNumber "947687-12-9".
- Cixutumumab fdaUniiCode "2285XW22DR".
- Cixutumumab wikiPageID "19840675".
- Cixutumumab wikiPageRevisionID "545471477".
- Cixutumumab atcPrefix "none".
- Cixutumumab c "6500".
- Cixutumumab casNumber "947687".
- Cixutumumab chemspiderid "NA".
- Cixutumumab h "10052".
- Cixutumumab hasPhotoCollection Cixutumumab.
- Cixutumumab kegg "D09328".
- Cixutumumab mabType "mab".
- Cixutumumab molecularWeight "146.3".
- Cixutumumab n "1724".
- Cixutumumab o "2036".
- Cixutumumab s "44".
- Cixutumumab source "u".
- Cixutumumab target Insulin-like_growth_factor_1_receptor.
- Cixutumumab type "mab".
- Cixutumumab unii "2285".
- Cixutumumab verifiedfields "changed".
- Cixutumumab verifiedrevid "458639103".
- Cixutumumab subject Category:Monoclonal_antibodies.
- Cixutumumab type Abstraction100002137.
- Cixutumumab type Antibody115027189.
- Cixutumumab type Chemical114806838.
- Cixutumumab type Compound114818238.
- Cixutumumab type Macromolecule114944888.
- Cixutumumab type Material114580897.
- Cixutumumab type Matter100020827.
- Cixutumumab type Molecule114682133.
- Cixutumumab type MonoclonalAntibodies.
- Cixutumumab type MonoclonalAntibody115029781.
- Cixutumumab type OrganicCompound114727670.
- Cixutumumab type Part113809207.
- Cixutumumab type PhysicalEntity100001930.
- Cixutumumab type Protein114728724.
- Cixutumumab type Relation100031921.
- Cixutumumab type Substance100019613.
- Cixutumumab type Thing100002452.
- Cixutumumab type Unit109465459.
- Cixutumumab type Drug.
- Cixutumumab type DrugProduct.
- Cixutumumab type FunctionalSubstance.
- Cixutumumab comment "Cixutumumab is a monoclonal antibody for the treatment of solid tumors.This drug was developed by ImClone Systems Inc. under the name IMC-A12.It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway.".
- Cixutumumab label "Cixutumumab".
- Cixutumumab label "Cixutumumab".
- Cixutumumab label "سيكسوتوموماب".
- Cixutumumab sameAs Cixutumumab.
- Cixutumumab sameAs m.04q2y34.
- Cixutumumab sameAs Q3678806.
- Cixutumumab sameAs Q3678806.
- Cixutumumab sameAs Cixutumumab.
- Cixutumumab wasDerivedFrom Cixutumumab?oldid=545471477.
- Cixutumumab isPrimaryTopicOf Cixutumumab.