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- Cobalamin_riboswitch abstract "Cobalamin riboswitch is a cis-regulatory element which is widely distributed in 5' untranslated regions of vitamin B12 (Colbalamin) related genes in bacteria. Riboswitches are metabolite binding domains within certain messenger RNAs (mRNAs) that serve as precision sensors for their corresponding targets. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression or translation of mRNA to yield a protein. Cobalamin in the form of adenosylcobalamin (Ado-CBL) is known to repress expression of proteins for vitamin B12 biosynthesis via a post-transcriptional regulatory mechanism that involves direct binding of Ado-CBL to 5' UTRs in relevant genes, preventing ribosome binding and translation of those genes. Before proof of riboswitch function, a conserved sequence motif called the B12 box was identified that corresponds to a part of the cobalamin riboswitch, and a more complete conserved structure was identified.Variants of the riboswitch consensus have been identified.".
- Cobalamin_riboswitch thumbnail RF00174.jpg?width=300.
- Cobalamin_riboswitch wikiPageID "11243898".
- Cobalamin_riboswitch wikiPageRevisionID "595687436".
- Cobalamin_riboswitch altsymbols "rli55".
- Cobalamin_riboswitch caption "Predicted secondary structure and sequence conservation of AdoCbl riboswitch".
- Cobalamin_riboswitch caption "Predicted secondary structure and sequence conservation of Cobalamin".
- Cobalamin_riboswitch hasPhotoCollection Cobalamin_riboswitch.
- Cobalamin_riboswitch id "RF00174".
- Cobalamin_riboswitch id "RF01482".
- Cobalamin_riboswitch name "AdoCbl riboswitch".
- Cobalamin_riboswitch name "Cobalamin riboswitch".
- Cobalamin_riboswitch rfam "RF00174".
- Cobalamin_riboswitch rfam "RF01482".
- Cobalamin_riboswitch rnaType Cis-regulatory_element.
- Cobalamin_riboswitch rnaType Riboswitch.
- Cobalamin_riboswitch symbol "AdoCbl_riboswitch".
- Cobalamin_riboswitch symbol "Cobalamin".
- Cobalamin_riboswitch taxDomain Bacteria.
- Cobalamin_riboswitch subject Category:Cis-regulatory_RNA_elements.
- Cobalamin_riboswitch subject Category:Riboswitch.
- Cobalamin_riboswitch type Abstraction100002137.
- Cobalamin_riboswitch type Cis-regulatoryRNAElements.
- Cobalamin_riboswitch type Cognition100023271.
- Cobalamin_riboswitch type Component105868954.
- Cobalamin_riboswitch type Concept105835747.
- Cobalamin_riboswitch type Content105809192.
- Cobalamin_riboswitch type Idea105833840.
- Cobalamin_riboswitch type Part105867413.
- Cobalamin_riboswitch type PsychologicalFeature100023100.
- Cobalamin_riboswitch comment "Cobalamin riboswitch is a cis-regulatory element which is widely distributed in 5' untranslated regions of vitamin B12 (Colbalamin) related genes in bacteria. Riboswitches are metabolite binding domains within certain messenger RNAs (mRNAs) that serve as precision sensors for their corresponding targets. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression or translation of mRNA to yield a protein.".
- Cobalamin_riboswitch label "Cobalamin riboswitch".
- Cobalamin_riboswitch sameAs m.02r4x66.
- Cobalamin_riboswitch sameAs Q5138686.
- Cobalamin_riboswitch sameAs Q5138686.
- Cobalamin_riboswitch sameAs Cobalamin_riboswitch.
- Cobalamin_riboswitch wasDerivedFrom Cobalamin_riboswitch?oldid=595687436.
- Cobalamin_riboswitch depiction RF00174.jpg.
- Cobalamin_riboswitch isPrimaryTopicOf Cobalamin_riboswitch.