Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Cocaine> ?p ?o. }
- Cocaine abstract "Cocaine (INN) (benzoylmethylecgonine, an ecgonine derivative) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" and the alkaloid suffix "-ine", forming "cocaine". It is a stimulant, an appetite suppressant, and a nonspecific voltage gated sodium channel blocker, which in turn causes it to produce anaesthesia at low doses. Biologically, cocaine acts as a serotonin–norepinephrine–dopamine reuptake inhibitor, also known as a triple reuptake inhibitor (TRI). It is addictive due to its effect on the mesolimbic reward pathway. It is markedly more dangerous than other CNS stimulants, including the entire amphetamine drug class, at high doses due to its effect on sodium channels, as blockade of Nav1.5 can cause sudden cardiac death.Unlike most molecules, cocaine has pockets with both high hydrophilic and lipophilic efficiency, violating the rule of hydrophilic-lipophilic balance. This causes it to cross the blood–brain barrier far better than other psychoactive chemicals[citation needed] and may even induce blood-brain barrier breakdown.It is controlled internationally by the Single Convention on Narcotic Drugs (Schedule I, preparation in Schedule III).".
- Cocaine atcPrefix "N01".
- Cocaine atcSuffix "BC01".
- Cocaine atcSupplemental ", ,".
- Cocaine casNumber "50-36-2".
- Cocaine chEBI "27958".
- Cocaine drugbank "DB00907".
- Cocaine fdaUniiCode "I5Y540LHVR".
- Cocaine iupacName "methyl (1R,2R,3S,5S)-3- (benzoyloxy)-8-methyl-8-azabicyclo[3.2.1] octane-2-carboxylate".
- Cocaine pubchem "5760".
- Cocaine thumbnail Kokain_-_Cocaine.svg?width=300.
- Cocaine wikiPageExternalLink dpdirect.jsp?name=Cocaine.
- Cocaine wikiPageExternalLink blsldiccocaine.htm.
- Cocaine wikiPageExternalLink chemdisp.xsql?chemical=COCAINE.
- Cocaine wikiPageExternalLink A10832384.
- Cocaine wikiPageExternalLink ?nnodeid=25482.
- Cocaine wikiPageExternalLink cocaine.shtml.
- Cocaine wikiPageExternalLink cocaine.
- Cocaine wikiPageExternalLink index.htm.
- Cocaine wikiPageExternalLink faq.htm.
- Cocaine wikiPageExternalLink modules.php?name=Articles&file=article&sid=45.
- Cocaine wikiPageID "7701".
- Cocaine wikiPageRevisionID "606435705".
- Cocaine atcPrefix "N01".
- Cocaine atcSuffix "BC01".
- Cocaine atcSupplemental ", ,".
- Cocaine bioavailability "Insufflated: 60–80%".
- Cocaine bioavailability "Nasal spray: 25–43%".
- Cocaine bioavailability "Oral: 33%".
- Cocaine boilingPoint "187".
- Cocaine c "17".
- Cocaine casNumber "50".
- Cocaine chebi "27958".
- Cocaine chembl "120901".
- Cocaine chemspiderid "10194104".
- Cocaine date "20110323134442".
- Cocaine date "20130822164343".
- Cocaine dependencyLiability "High".
- Cocaine df "yes".
- Cocaine drugbank "DB00907".
- Cocaine eliminationHalfLife "3600.0".
- Cocaine excretion "Renal".
- Cocaine h "21".
- Cocaine hasPhotoCollection Cocaine.
- Cocaine image "Cocaine3DanBS.gif".
- Cocaine inchi "1".
- Cocaine iupacName "methyl -3- -8-methyl-8-azabicyclo[3.2.1] octane-2-carboxylate".
- Cocaine iupharLigand "2286".
- Cocaine kegg "D00110".
- Cocaine legalAu "Schedule 8".
- Cocaine legalCa "Schedule I".
- Cocaine legalUk "A".
- Cocaine legalUn "N I III".
- Cocaine legalUs "Schedule II".
- Cocaine meltingPoint "98".
- Cocaine metabolism CYP3A4.
- Cocaine metabolism Liver.
- Cocaine molecularWeight "303.353".
- Cocaine n "1".
- Cocaine o "4".
- Cocaine pdbLigand "COC".
- Cocaine pregnancyUs "C".
- Cocaine pubchem "5760".
- Cocaine routesOfAdministration "Topical, oral, insufflation, IV, PO".
- Cocaine smiles "CN1[C@H]2CC[C@@H]1[C@@H][C@@H]C2".
- Cocaine solubility "HCl: 1800–2500".
- Cocaine stdinchi "1".
- Cocaine stdinchikey "ZPUCINDJVBIVPJ-LJISPDSOSA-N".
- Cocaine synonyms "methylbenzoylecgonine, benzoylmethylecgonine, ecgonine methyl ester benzoate, 2b-Carbomethoxy −3b-benzoyloxy tropane".
- Cocaine title "A look at the Evidence for Cocaine in Mummies".
- Cocaine title "Cocaine Market Data and Value-Havocscope Black Markets".
- Cocaine unii "I5Y540LHVR".
- Cocaine url cocaine.
- Cocaine url modules.php?name=Articles&file=article&sid=45.
- Cocaine verifiedfields "changed".
- Cocaine verifiedrevid "477165921".
- Cocaine watchedfields "changed".
- Cocaine width "250".
- Cocaine width "300".
- Cocaine subject Category:Addictive_drugs.
- Cocaine subject Category:Anorectics.
- Cocaine subject Category:Benzoates.
- Cocaine subject Category:Carboxylate_esters.
- Cocaine subject Category:Cardiac_stimulants.
- Cocaine subject Category:Cocaine.
- Cocaine subject Category:Euphoriants.
- Cocaine subject Category:German_inventions.
- Cocaine subject Category:Local_anesthetics.
- Cocaine subject Category:Methyl_esters.
- Cocaine subject Category:Otologicals.
- Cocaine subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- Cocaine subject Category:Sigma_agonists.
- Cocaine subject Category:Stimulants.
- Cocaine subject Category:Sympathomimetic_amines.
- Cocaine subject Category:Teratogens.
- Cocaine subject Category:Tropane_alkaloids_found_in_Erythroxylum_coca.
- Cocaine subject Category:Vasoconstrictors.
- Cocaine type Drug.
- Cocaine type DrugProduct.
- Cocaine type FunctionalSubstance.