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- Conserved_signature_indels abstract "Conserved signature inserts and deletions (CSIs) in protein sequences provide an important category of molecular markers for understanding phylogenetic relationships. CSIs, brought about by rare genetic changes, provide useful phylogenetic markers that are generally of defined size and they are flanked on both sides by conserved regions to ensure their reliability. While indels can be arbitrary inserts or deletions, CSIs are defined as only those protein indels that are present within conserved regions of the protein.The CSIs that are restricted to a particular Clade or group of species, generally provide good phylogenetic markers of common evolutionary descent. Due to the rarity and highly specific nature of such changes, it is less likely that they could arise independently by either Convergent or parallel evolution (i.e. homoplasy)or synapomorphy. Other confounding factors such as differences in evolutionary rates at different sites or among different species also generally do not affect the interpretation of a CSI. By determining the presence or absence of CSIs in an out-group species, one can infer whether the ancestral form of the CSI was an insert or deletion and this can be used to develop a rooted phylogenetic relationship among organisms.Most CSIs that have been identified have been found to exhibit high predictive value and they generally retain the specificity for the originally identified clades of species . Therefore, based upon their presence or absence, it should be possible to identify both known and even previously unknown species belonging to these groups in different environments.".
- Conserved_signature_indels thumbnail Group_indel_picture.png?width=300.
- Conserved_signature_indels wikiPageID "35155103".
- Conserved_signature_indels wikiPageRevisionID "578843422".
- Conserved_signature_indels hasPhotoCollection Conserved_signature_indels.
- Conserved_signature_indels subject Category:Molecular_biology.
- Conserved_signature_indels comment "Conserved signature inserts and deletions (CSIs) in protein sequences provide an important category of molecular markers for understanding phylogenetic relationships. CSIs, brought about by rare genetic changes, provide useful phylogenetic markers that are generally of defined size and they are flanked on both sides by conserved regions to ensure their reliability.".
- Conserved_signature_indels label "Conserved signature indels".
- Conserved_signature_indels sameAs m.0jt48z4.
- Conserved_signature_indels sameAs Q5163163.
- Conserved_signature_indels sameAs Q5163163.
- Conserved_signature_indels wasDerivedFrom Conserved_signature_indels?oldid=578843422.
- Conserved_signature_indels depiction Group_indel_picture.png.
- Conserved_signature_indels isPrimaryTopicOf Conserved_signature_indels.