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- Coombs_test abstract "A Coombs test (also known as Coombs' test, antiglobulin test or AGT) is either of two clinical blood tests used in immunohematology and immunology. The two Coombs tests are the direct Coombs test (DCT, also known as direct antiglobulin test or DAT), and the indirect Coombs test (also known as indirect antiglobulin test or IAT).The Direct Coombs test is used to test for autoimmune hemolytic anemia; i.e., a condition of a low count of red blood cells (aka RBCs) caused by immune system lysis or breaking of RBC membranes causing RBC destruction.In certain diseases or conditions an individual's blood may contain IgG antibodies that can specifically bind to antigens on the RBC surface membrane, and their circulating RBCs can become coated with IgG alloantibodies and/or IgG autoantibodies. Complement proteins may subsequently bind to the bound antibodies and cause RBC destruction. The direct Coombs test is used to detect these antibodies or complement proteins that are bound to the surface of red blood cells; a blood sample is taken and the RBCs are washed (removing the patient's own plasma) and then incubated with antihuman globulin (also known as "Coombs reagent"). If this produces agglutination of RBCs, the direct Coombs test is positive, a visual indication that antibodies (and/or complement proteins) are bound to the surface of red blood cells.The indirect Coombs test is used in prenatal testing of pregnant women, and in testing blood prior to a blood transfusion. It detects antibodies against RBCs that are present unbound in the patient's serum. In this case, serum is extracted from the blood sample taken from the patient. Then, the serum is incubated with RBCs of known antigenicity; that is, RBCs with known reference values from other patient blood samples. If agglutination occurs, the indirect Coombs test is positive.".
- Coombs_test thumbnail Coombs_test_schematic.png?width=300.
- Coombs_test wikiPageExternalLink topic808.htm.
- Coombs_test wikiPageExternalLink tmu10-2000.htm.
- Coombs_test wikiPageExternalLink 69t2.jsp.
- Coombs_test wikiPageExternalLink 003343.htm.
- Coombs_test wikiPageExternalLink 003344.htm.
- Coombs_test wikiPageID "1461217".
- Coombs_test wikiPageRevisionID "592771055".
- Coombs_test hasPhotoCollection Coombs_test.
- Coombs_test medlineplus "3344".
- Coombs_test meshid "D003298".
- Coombs_test name "Coombs test".
- Coombs_test subject Category:Blood_tests.
- Coombs_test subject Category:Immunologic_tests.
- Coombs_test subject Category:Transfusion_medicine.
- Coombs_test type Abstraction100002137.
- Coombs_test type Act100030358.
- Coombs_test type Activity100407535.
- Coombs_test type Assay100791527.
- Coombs_test type Attempt100786195.
- Coombs_test type Biopsy105740929.
- Coombs_test type BloodTest105742551.
- Coombs_test type BloodTests.
- Coombs_test type Cognition100023271.
- Coombs_test type DiagnosticTest105739043.
- Coombs_test type Event100029378.
- Coombs_test type Experiment105798043.
- Coombs_test type HigherCognitiveProcess105770664.
- Coombs_test type ImmunologicTests.
- Coombs_test type Inquiry105797597.
- Coombs_test type ProblemSolving105796750.
- Coombs_test type Process105701363.
- Coombs_test type PsychologicalFeature100023100.
- Coombs_test type Test100791078.
- Coombs_test type Thinking105770926.
- Coombs_test type Trial105799212.
- Coombs_test type YagoPermanentlyLocatedEntity.
- Coombs_test comment "A Coombs test (also known as Coombs' test, antiglobulin test or AGT) is either of two clinical blood tests used in immunohematology and immunology.".
- Coombs_test label "Antiglobuline".
- Coombs_test label "Antiglobulinetest".
- Coombs_test label "Antikörpersuchtest".
- Coombs_test label "Coombs test".
- Coombs_test label "Odczyn antyglobulinowy Coombsa".
- Coombs_test label "Prueba de Coombs".
- Coombs_test label "Test di Coombs".
- Coombs_test label "Teste de Coombs".
- Coombs_test label "Реакция Кумбса".
- Coombs_test label "クームス試験".
- Coombs_test sameAs Coombsův_test.
- Coombs_test sameAs Antikörpersuchtest.
- Coombs_test sameAs Prueba_de_Coombs.
- Coombs_test sameAs Antiglobuline.
- Coombs_test sameAs Test_di_Coombs.
- Coombs_test sameAs クームス試験.
- Coombs_test sameAs Antiglobulinetest.
- Coombs_test sameAs Odczyn_antyglobulinowy_Coombsa.
- Coombs_test sameAs Teste_de_Coombs.
- Coombs_test sameAs m.053cch.
- Coombs_test sameAs Q740056.
- Coombs_test sameAs Q740056.
- Coombs_test sameAs Coombs_test.
- Coombs_test wasDerivedFrom Coombs_test?oldid=592771055.
- Coombs_test depiction Coombs_test_schematic.png.
- Coombs_test isPrimaryTopicOf Coombs_test.